Evidence map›Paper›PMID 34593639›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

PRAMEF2-mediated dynamic regulation of YAP signaling promotes tumorigenesis.

Madhurima Ghosh, Sanjeev Das

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Targeting ubiquitination in disease and therapy.Signal transduction and targeted therapy · 2025
    Review
  2. Article
  3. Article
  4. METTL14 suppresses the expression of YAP1 and the stemness of triple-negative breast cancer.Journal of experimental & clinical cancer research : CR · 2024
    Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Madhurima GhoshMolecular Oncology Laboratory, National Institute of Immunology, New Delhi 110067, India.
Sanjeev DasMolecular Oncology Laboratory, National Institute of Immunology, New Delhi 110067, India sdas@nii.ac.in.
National Institute of Immunology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PRAMEF2 is a member of the PRAME multigene family of cancer testis antigens, which serve as prognostic markers for several cancers. However, molecular mechanisms underlying its role in tumorigenesis remain poorly understood. Here, we report that

Indexed as

Adaptor Proteins, Signal TransducingAnimalsBreast NeoplasmsCarcinogenesisCell Cycle ProteinsCell Line, TumorCell ProliferationFemaleHumansMCF-7 CellsMiceProtein Serine-Threonine KinasesSignal TransductionTranscription FactorsUbiquitinationAdaptor Proteins, Signal TransducingCell Cycle ProteinsProtein Serine-Threonine KinasesTranscription FactorsYY1AP1 protein, humanPRAMEF2tumorigenesisubiquitylationYAP

Identifiers

PMID34593639
PMCPMC8501796
OpenAlexW3202885150

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.