Evidence map›Paper›PMID 34593630›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Automated design of pulse sequences for magnetic resonance fingerprinting using physics-inspired optimization.

Stephen P Jordan, Siyuan Hu, Ignacio Rozada, Debra F McGivney, Rasim Boyacioğlu, Darryl C Jacob, Sherry Huang, Michael Beverland, Helmut G Katzgraber, Matthias Troyer and 2 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 4 citations in OpenAlex.

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  7. Accurate MRF-Based 3D Multi-Channel BNMR in biomedicine · 2025
    Article
  8. Article
  9. Time-resolved MR fingerprinting for TMagnetic resonance in medicine · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Stephen P JordanQuantum Systems, Microsoft, Redmond, WA 98052.ORCID 0000-0003-1035-1827
Siyuan HuBiomedical Engineering, Case Western Reserve University, Cleveland, OH 44106.
Ignacio RozadaOptimization Solutions, 1QBit, Vancouver, BC V6E 4B1, Canada.ORCID 0000-0002-4878-1868
Debra F McGivneyBiomedical Engineering, Case Western Reserve University, Cleveland, OH 44106.
Rasim BoyacioğluRadiology Department, Case Western Reserve University, Cleveland, OH 44106.
Darryl C JacobDepartment of Physics and Astronomy, Texas A & M University, College Station, TX 77843.
Sherry HuangBiomedical Engineering, Case Western Reserve University, Cleveland, OH 44106.ORCID 0000-0003-0614-6628
Michael BeverlandQuantum Systems, Microsoft, Redmond, WA 98052.ORCID 0000-0003-0954-4509
Helmut G KatzgraberQuantum Systems, Microsoft, Redmond, WA 98052.ORCID 0000-0003-3341-9943
Matthias TroyerQuantum Systems, Microsoft, Redmond, WA 98052.
Mark A GriswoldRadiology Department, Case Western Reserve University, Cleveland, OH 44106.
Dan MaBiomedical Engineering, Case Western Reserve University, Cleveland, OH 44106; dan.ma@case.edu.ORCID 0000-0003-1664-9579
Case Western Reserve University · USMicrosoft (United States) · USApplied Optimization (United States) · USTexas A&M University · US

Funding

MR Fingerprinting for EpilepsyR01NS109439 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI Dan Ma, Zhong Irene Wang · 2019 to 2026
$4.2M
Optimization of Magnetic Resonance Fingerprintingusing Quantum Inspired AlgorithmsR21EB029658 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI MCGIVNEY, DEBRA · 2021 to 2023
$644k
A Framework to Design 3D Quantitative Magnetic Resonance Fingerprinting (MRF) Scans and Reduce Patient AnxietyR21EB026764 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI MA, DAN · 2018 to 2020
$641k
NIBIB NIH HHS R21 EB026764NIBIB NIH HHS R21 EB029658NINDS NIH HHS R01 NS109439
6 · The paper itself

Abstract

Magnetic resonance fingerprinting (MRF) is a method to extract quantitative tissue properties such as [Formula: see text] and [Formula: see text] relaxation rates from arbitrary pulse sequences using conventional MRI hardware. MRF pulse sequences have thousands of tunable parameters, which can be chosen to maximize precision and minimize scan time. Here, we perform de novo automated design of MRF pulse sequences by applying physics-inspired optimization heuristics. Our experimental data suggest that systematic errors dominate over random errors in MRF scans under clinically relevant conditions of high undersampling. Thus, in contrast to prior optimization efforts, which focused on statistical error models, we use a cost function based on explicit first-principles simulation of systematic errors arising from Fourier undersampling and phase variation. The resulting pulse sequences display features qualitatively different from previously used MRF pulse sequences and achieve fourfold shorter scan time than prior human-designed sequences of equivalent precision in [Formula: see text] and [Formula: see text] Furthermore, the optimization algorithm has discovered the existence of MRF pulse sequences with intrinsic robustness against shading artifacts due to phase variation.

Indexed as

AlgorithmsAutomationBrainComputer SimulationEpilepsyHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingNeoplasmsPhantoms, Imagingmagnetic resonance fingerprintingmagnetic resonance imagingoptimizationpulse sequence design

Identifiers

PMID34593630
PMCPMC8501900
OpenAlexW3170018806

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.