Evidence map›Paper›PMID 34593610›Full record

ArticleMolecular cancer research : MCR2021

MYC Hyperactivates Wnt Signaling in

Priyanka Sehgal, Claudia Lanauze, Xin Wang, Katharina E Hayer, Manuel Torres-Diz, N Adrian Leu, Yogev Sela, Ben Z Stanger, Christopher J Lengner, Andrei Thomas-Tikhonenko

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

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  11. Drug-Resistant Stem Cells: Novel Approach for Colon Cancer Therapy.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Priyanka SehgalDivision of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.ORCID 0000-0003-2231-4564
Claudia LanauzeDivision of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Xin WangDepartment of Biomedical Sciences, School of Veterinary Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Katharina E HayerThe Bioinformatics Group, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.ORCID 0000-0002-1463-3111
Manuel Torres-DizDivision of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.ORCID 0000-0002-5487-8113
N Adrian LeuDepartment of Biomedical Sciences, School of Veterinary Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Yogev SelaDepartment of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Ben Z StangerDepartment of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0003-0410-4037
Christopher J LengnerDepartment of Biomedical Sciences, School of Veterinary Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Andrei Thomas-TikhonenkoDivision of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. andreit@pennmedicine.upenn.edu.ORCID 0000-0002-2739-2206
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

IMMUNOBIOLOGY OF NORMAL AND NEOPLASTIC LYMPHOCYTEST32CA009140 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Malay Haldar, WARREN S PEAR · 1985 to 2026
$16.1M
Deregulation of MSI RNA-binding proteins promotes intestinal tumorigenesisR01CA168654 · NCI · UNIVERSITY OF PENNSYLVANIA · PI LENGNER, CHRISTOPHER JOACHIM · 2012 to 2021
$3.7M
The Myc - miR-17-92 axis in colorectal cancersR01CA196299 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI THOMAS-TIKHONENKO, ANDREI · 2015 to 2019
$1.9M
NCI NIH HHS R01 CA168654NCI NIH HHS R01 CA196299NCI NIH HHS T32 CA009140
6 · The paper itself

Abstract

Activation of Wnt signaling is among the earliest events in colon cancer development. It is achieved either via activating mutations in the

Indexed as

Adaptor Proteins, Signal TransducingAnimalsCell Line, TumorCell ProliferationColorectal NeoplasmsDisease Models, AnimalHumansMiceMicroRNAsTransfectionWnt Signaling PathwayAdaptor Proteins, Signal TransducingDkk3 protein, mouseMicroRNAsMIRN92 microRNA, human

Identifiers

PMID34593610
PMCPMC8642317
OpenAlexW3203190558

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.