Evidence map›Paper›PMID 34593608›Full record

ArticleMolecular cancer research : MCR2021

Ellen Voigt, Madeline Wallenburg, Hannah Wollenzien, Ethan Thompson, Kirtana Kumar, Joshua Feiner, Moira McNally, Hunter Friesen, Malini Mukherjee, Yohannes Afeworki and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Distinct molecular subtypes of KRASClinical and translational medicine · 2025
    Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Actionable Driver Events in Small Cell Lung Cancer.International journal of molecular sciences · 2023
    Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Ellen Voigt *Cancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, South Dakota.
Madeline Wallenburg *Cancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, South Dakota.ORCID 0000-0002-9232-4656
Hannah WollenzienCancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, South Dakota.
Ethan ThompsonCancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, South Dakota.
Kirtana KumarCancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, South Dakota.
Joshua FeinerDakota Wesleyan University, Mitchell, South Dakota.
Moira McNallyCancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, South Dakota.ORCID 0000-0001-8780-5466
Hunter FriesenCancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, South Dakota.
Malini MukherjeeFunctional Genomics & Bioinformatics Core, Sanford Research, Sioux Falls, South Dakota.
Yohannes AfeworkiFunctional Genomics & Bioinformatics Core, Sanford Research, Sioux Falls, South Dakota.
Michael S KaretaCancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, South Dakota. michael.kareta@sanfordhealth.org.ORCID 0000-0002-6980-9065
Sanford Research · USDakota Wesleyan University · USSouth Dakota State University · USUniversity of South Dakota · US

Funding

Yeast 2 HybridP20GM103620 · NIGMS · SANFORD RESEARCH/USD · PI ROUX, KYLE J · 2013 to 2023
$24.2M
The Impact of PD-1 Inhibition on Immune-Response to ChemoradiotherapyP20GM103548 · NIGMS · SANFORD RESEARCH/USD · PI MISKIMINS, W KEITH · 2012 to 2020
$20.8M
Oncogenic mechanism of Sox2 in Rb-deficient tumorsR01CA233661 · NCI · SANFORD RESEARCH/USD · PI KARETA, MICHAEL S. · 2019 to 2023
$1.9M
The Pediatric Biomedical Research ProgramR25HD097633 · NICHD · SANFORD RESEARCH/USD · PI LEE, LANCE, WEIMER, JILL M · 2019 to 2023
$527k
NCI NIH HHS R01 CA233661NICHD NIH HHS R25 HD097633NIGMS NIH HHS P20 GM103548NIGMS NIH HHS P20 GM103620
6 · The paper itself

Abstract

Although many cancer prognoses have improved in the past 50 years due to advancements in treatments, there has been little improvement in therapies for small-cell lung cancer (SCLC). One promising avenue to improve treatment for SCLC is to understand its underlying genetic alterations that drive its formation, growth, and cellular heterogeneity.

Indexed as

AnimalsCell Line, TumorHumansLung NeoplasmsMiceOncogenesSmall Cell Lung CarcinomaSOXB1 Transcription FactorsSox2 protein, mouseSOXB1 Transcription Factors

Identifiers

PMID34593608
PMCPMC8642303
OpenAlexW3204692469

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.