Evidence map›Paper›PMID 34593497›Full record

ArticleBMJ open2021

Improved diagnostics of infectious diseases in emergency departments: a protocol of a multifaceted multicentre diagnostic study.

Helene Skjøt-Arkil, Anne Heltborg, Morten Hjarnø Lorentzen, Mariana Bichuette Cartuliares, Mathias Amdi Hertz, Ole Graumann, Flemming S Rosenvinge, Eva Rabing Brix Petersen, Claus Østergaard, Christian B Laursen and 4 more

9 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 9 registered trials, which are not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04645030 completednot on this map

The Value of Ultralow Dosis CT and Ultrasound in the Diagnosing of Pneumonia in the Emergency Department

TypeobservationalSponsorUniversity of Southern DenmarkRan2021 to 2022Enrolled411ConditionsRespiratory Tract InfectionsArmsUltra low-dose computer thermography, lung ultrasound
NCT04651244 completednot on this map

Diagnostic Imaging of Acute Pyelonephritis - Part of the INDEED Study (Infectious Diseases in Emergency Departments)

TypeobservationalSponsorUniversity of Southern DenmarkRan2021 to 2022Enrolled19ConditionsPyelonephritis AcuteArmsMRI, Ultrasound performed by a radiologist, Point of care ultrasound
NCT04651712 nacompletednot on this map

The Effect of a Point-of-care Sputum Specimen Assay on Antibiotic Treatment of Patients Admitted Acutely With Suspected Pneumonia: A Multicenter Randomized Controlled Trial

TypeinterventionalSponsorUniversity of Southern DenmarkRan2021 to 2022Enrolled290ConditionsPneumonia, BacterialArmsPOC-PCR
NCT04652167 completednot on this map

What is the Diagnostic and Prognostic Accuracy of C-reactive Protein, Serum Procalcitonin and Soluble Urokinase Plasminogen Activator Receptor in the Initial Investigation of Patients With Suspected Community-acquired Pneumonia

TypeobservationalSponsorUniversity of Southern DenmarkRan2021 to 2022Enrolled411ConditionsPneumonia, BacterialArmsPCT, suPAR, Standard care
NCT04661085 completednot on this map

A Descriptive Study of Patients Suspected With Infection in the Emergency Department, With a Special Focus on Infection With Unknown Origin.

TypeobservationalSponsorUniversity of Southern DenmarkRan2021 to 2022Enrolled966ConditionsInfectionArmsBroader Medical history and clinical tests
NCT04667195 completednot on this map

Clinical Characteristics of Acutely Hospitalized Adults With Acute Pyelonephritis in the Emergency Department: A Cross-sectional Study

TypeobservationalSponsorUniversity of Southern DenmarkRan2021 to 2022Enrolled966ConditionsAcute PyelonephritisArmsClinical assessment
NCT04681963 completednot on this map

Clinical Characteristics of Hospitalized Adults With Community-acquired- Pneumonia at the Emergency Department: A Cross-sectional Study

TypeobservationalSponsorUniversity of Southern DenmarkRan2021 to 2022Enrolled966ConditionsPneumoniaArmsClinical Assessment within 4 hours of admission
NCT04686292 completednot on this map

Diagnostic Accuracy of Urine Flow Cytometry in Diagnosing and Excluding Bacteruria in the Emergency Department

TypeobservationalSponsorUniversity of Southern DenmarkRan2021 to 2022Enrolled966ConditionsAcute InfectionArmsurine flow cytometry
NCT04686318 completednot on this map

What is the Diagnostic and Prognostic Accuracy of C-reactive Protein, Serum Procalcitonin and Soluble Urokinase Plasminogen Activator Receptor in the Initial Investigation of Patients With Suspected Acute Pyelonephritis

TypeobservationalSponsorUniversity of Southern DenmarkRan2021 to 2022Enrolled229ConditionsAcute PyelonephritisArmsBiomarkers for acute pyelonephritis
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
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  9. Article
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  11. Can clinicians identify community-acquired pneumonia on ultralow-dose CT? A diagnostic accuracy study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2024
    Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Helene Skjøt-ArkilEmergency Department, University Hospital of Southern Denmark, Aabenraa, Denmark Helene.Skjoet-Arkil@rsyd.dk.ORCID 0000-0002-2236-6375
Anne HeltborgDepartment of Regional Health Research, University of Southern Denmark Faculty of Health Sciences, Odense, Denmark.
Morten Hjarnø LorentzenEmergency Department, University Hospital of Southern Denmark, Aabenraa, Denmark.
Mariana Bichuette CartuliaresEmergency Department, University Hospital of Southern Denmark, Aabenraa, Denmark.
Mathias Amdi HertzDepartment of Infectious Diseases, Odense University Hospital, Odense, Denmark.ORCID 0000-0002-8064-7642
Ole GraumannDepartment of Clinical Research, University of Southern Denmark Faculty of Health Sciences, Odense, Denmark.
Flemming S RosenvingeDepartment of Clinical Microbiology, Odense University Hospital, Odense, Denmark.
Eva Rabing Brix PetersenBlood Samples, Biochemistry and Immunology, University Hospital of Southern Denmark, Aabenraa, Denmark.
Claus ØstergaardDepartment of Clinical Microbiology, University Hospital of Southern Denmark, Vejle, Denmark.
Christian B LaursenDepartment of Clinical Research, University of Southern Denmark Faculty of Health Sciences, Odense, Denmark.
Thor Aage SkovstedBlood Samples, Biochemistry and Immunology, University Hospital of Southern Denmark, Aabenraa, Denmark.
Stefan PosthDepartment of Clinical Research, University of Southern Denmark Faculty of Health Sciences, Odense, Denmark.
Ming ChenDepartment of Regional Health Research, University of Southern Denmark Faculty of Health Sciences, Odense, Denmark.
Christian Backer MogensenEmergency Department, University Hospital of Southern Denmark, Aabenraa, Denmark.ORCID 0000-0002-8254-089X
University of Southern Denmark · DKOdense University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe major obstacle in prescribing an appropriate and targeted antibiotic treatment is insufficient knowledge concerning METHODS AND ANALYSIS: It is a multifaceted multicentre diagnostic study, including 1000 adults admitted with suspicion of an acute infection. Participants will, within the first 24 hours of admission, undergo additional diagnostic tests including infection markers, POC urine flow cytometry, POC analysis of sputum, POC and specialist ultrasound, and ULDCT. The primary reference standard is an assigned diagnosis determined by a panel of experts. ETHICS, DISSEMINATION AND REGISTRATION: Approved by Regional Committees on Health Research Ethics for Southern Denmark, Danish Data Protection Agency and clinicaltrials.gov. Results will be presented in peer-reviewed journals, and positive, negative and inconclusive results will be published. TRIAL REGISTRATION NUMBERS: NCT04661085, NCT04681963, NCT04667195, NCT04652167, NCT04686318, NCT04686292, NCT04651712, NCT04645030, NCT04651244.

Indexed as

BacteriuriaCommunicable DiseasesAdultEmergency Service, HospitalHumansMulticenter Studies as TopicPoint-of-Care TestingUltrasonographyaccident & emergency medicinecomputed tomographydiagnostic microbiologydiagnostic radiologymicrobiologyultrasound

Identifiers

PMID34593497
PMCPMC8487181
OpenAlexW3202927332

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

and 3 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.