Evidence map›Paper›PMID 34593340›Full record

ReviewOral surgery, oral medicine, oral pathology and oral radiology2021

Anticholinergic medication: Related dry mouth and effects on the salivary glands.

Szilvia Arany, Dorota T Kopycka-Kedzierawski, Thomas V Caprio, Gene E Watson

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oral surgery, oral medicine, oral pathology and oral radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 4 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 64 citations in OpenAlex.

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  11. Dental Caries in Older Adults: A Narrative Review for Non-Dental Providers.International journal of environmental research and public health · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Szilvia AranySpecialty Care, Department of General Dentistry, Eastman Institute of Oral Health, University of Rochester, Rochester, NY, USA. Electronic address: Szilvia_arany@urmc.rochester.edu.
Dorota T Kopycka-KedzierawskiDepartment of Community Dentistry and Oral Disease Prevention, University of Rochester, Rochester, NY, USA; Center for Oral Biology, University of Rochester, Rochester, NY, USA.
Thomas V CaprioDivision of Geriatrics and Aging, Department of Medicine, University of Rochester, Rochester, NY, USA.
Gene E WatsonCenter for Oral Biology, University of Rochester, Rochester, NY, USA; Department of Dentistry, University of Rochester, Rochester, NY, USA; Department of Environmental Medicine and Pharmacology and Physiology, University of Rochester, Rochester, NY, USA.
University of Rochester · USUniversity of Rochester Medical Center · US

Funding

Impact of Anticholinergic Medication on Salivary Function; Exploring Potential Genetic Markers for Dry MouthK23DE031021 · NIDCR · UNIVERSITY OF ROCHESTER · PI ARANY, SZILVIA · 2021 to 2025
$638k
NIDCR NIH HHS K23 DE031021
6 · The paper itself

Abstract

objectiveSalivary glands are among the most sensitive target organs of medications with anticholinergic (AC) properties, interrupting the neural stimulation of saliva secretion and reducing saliva flow. Hyposalivation results in dry mouth, leading to dental caries, intraoral infection, orofacial pain, problems with speaking and swallowing, and diminished oral health--related quality of life. Current understanding of the pharmacokinetics of AC medications and their effect on muscarinic receptors in the salivary glands were reviewed to assist clinicians in predicting salivary damage in patients with AC medication-induced dry mouth. STUDY

designWe summarized the literature related to the mechanisms and properties of AC medications, anticholinergic adverse effects, and their effect on salivary function and management strategies to prevent oral health damage.

resultsAlthough a large number of studies reported on the frequencies of medication-induced dry mouth, we found very limited data on predicting individual susceptibility to AC medication--caused hyposalivation and no prospective clinical studies addressing this issue.

conclusionDry mouth is most frequently caused by medications with AC properties, which interrupt the neural stimulation of saliva secretion. Interdisciplinary care should guide pharmacotherapeutics and dental interventions should aim in preventing AC salivary adverse effects and reducing the oral health burden from AC medication-induced dry mouth.

Indexed as

Dental CariesXerostomiaCholinergic AntagonistsHumansQuality of LifeSalivaSalivary GlandsCholinergic Antagonists

Identifiers

PMID34593340
PMCPMC9112430
OpenAlexW3197654498

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.