Evidence map›Paper›PMID 34593321›Full record

ReviewTrends in cognitive sciences2021

From exploration to exploitation: a shifting mental mode in late life development.

R Nathan Spreng, Gary R Turner

Abstract readReview
In one paragraph

Review in Trends in cognitive sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Prefrontal Default Mode Network Interactions with Posterior Hippocampus during Exploration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  7. Article
  8. Article
  9. Individual differences in sequential decision-making.bioRxiv : the preprint server for biology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Aging Impacts Basic Auditory and Timing Processes.The European journal of neuroscience · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Locus coeruleus integrity is related to an exploitation-based decision-making bias in older adulthood.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

R Nathan SprengLaboratory of Brain and Cognition, Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, QC H3A 2B4, Canada; McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada; Departments of Psychiatry and Psychology, McGill University, Montreal, QC H3A 0G4, Canada. Electronic address: nathan.spreng@mcgill.ca.
Gary R TurnerDepartment of Psychology, York University, Toronto, ON M3J 1P3, Canada.

Funding

Uncovering and Surveilling Financial Deception Risk in Aging (Diversity Supplement to 1R01AG057764-01A1)R01AG057764 · NIA · UNIVERSITY OF FLORIDA · PI EBNER, NATALIE C, SPRENG, ROBERT NATHAN · 2018 to 2022
$2.5M
Investigating the impact of loneliness on brain aging and pre-symptomatic Alzheimer's disease progressionR01AG068563 · NIA · MCGILL UNIVERSITY · PI BZDOK, DANILO, SPRENG, ROBERT NATHAN · 2020 to 2024
$2.3M
NIA NIH HHS R01 AG057764NIA NIH HHS R01 AG068563
6 · The paper itself

Abstract

Changes in cognition, affect, and brain function combine to promote a shift in the nature of mentation in older adulthood, favoring exploitation of prior knowledge over exploratory search as the starting point for thought and action. Age-related exploitation biases result from the accumulation of prior knowledge, reduced cognitive control, and a shift toward affective goals. These are accompanied by changes in cortical networks, as well as attention and reward circuits. By incorporating these factors into a unified account, the exploration-to-exploitation shift offers an integrative model of cognitive, affective, and brain aging. Here, we review evidence for this model, identify determinants and consequences, and survey the challenges and opportunities posed by an exploitation-biased mental mode in later life.

Indexed as

AgingCognitionAgedAttentionBrainHumansRewardagingdecision makingexploitexploreolder adults

Identifiers

PMID34593321
PMCPMC8844884

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.