Evidence map›Paper›PMID 34593014›Full record

ArticleMolecular neurodegeneration2021

METTL3-dependent RNA m

Fanpeng Zhao, Ying Xu, Shichao Gao, Lixia Qin, Quillan Austria, Sandra L Siedlak, Kinga Pajdzik, Qing Dai, Chuan He, Wenzhang Wang and 3 more

Open access · goldAbstract read
In one paragraph

Article in Molecular neurodegeneration, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers.

0numbers the graph read from it
0cells of the map it votes in
128citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

128 citing papers in PubMed, 186 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Targeting mNature communications · 2026
    Article
  6. mNature reviews. Neuroscience · 2026
    Review
  7. Article
  8. Article
  9. Riboregulation: a non-canonical tau function.Molecular neurodegeneration · 2026
    Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. METTL3-mediated mTranslational psychiatry · 2026
    Article

68 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Fanpeng ZhaoDepartment of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA.
Ying XuDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, the State University of New York, Buffalo, NY, 14214, USA.
Shichao GaoDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, the State University of New York, Buffalo, NY, 14214, USA.
Lixia QinDepartment of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA.
Quillan AustriaDepartment of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA.
Sandra L SiedlakDepartment of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA.
Kinga PajdzikDepartment of Chemistry, The University of Chicago, Chicago, IL, USA.
Qing DaiDepartment of Chemistry, The University of Chicago, Chicago, IL, USA.
Chuan HeDepartment of Chemistry, The University of Chicago, Chicago, IL, USA.
Wenzhang WangDepartment of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA.
James M O'DonnellDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, the State University of New York, Buffalo, NY, 14214, USA.
Beisha TangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xiongwei ZhuDepartment of Pathology, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA. xiongwei.zhu@case.edu.ORCID 0000-0003-2092-6508
Cornell University · USUniversity at Buffalo, State University of New York · USCentral South University · CNUniversity of Chicago · USHoward Hughes Medical Institute · US

Funding

Translational and Therapeutics CoreP30AG072959 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI Jonathan L Haines · 2021 to 2026
$23.9M
Translational Therapeutics CoreP30AG062428 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI LEVERENZ, JAMES BRUCE · 2019 to 2020
$5.0M
Molecular Mechanisms Underlying Mitochondrial Dynamics Abnormalities in Alzheimer DiseaseRF1AG049479 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI ZHU, XIONGWEI · 2016 to 2016
$2.6M
Epigenomic Mechanism of Parkinson's DiseaseR01NS083498 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI ZHU, XIONGWEI · 2013 to 2015
$604k
Leica SP8 Confocal with Hyvolution2 DeconvolutionS10OD024996 · OD · CASE WESTERN RESERVE UNIVERSITY · PI IMANISHI, YOSHIKAZU · 2018 to 2018
$594k
NIA NIH HHS P30 AG062428NIA NIH HHS P30 AG072959NIA NIH HHS RF1 AG049479NIH HHS S10 OD024996NINDS NIH HHS R01 NS083498
6 · The paper itself

Abstract

backgroundN6-methyladenosine (m

methodsWe investigated the m

resultsWe found decreased neuronal m

conclusionsCollectively, these data suggested that METTL3 reduction-mediated m

Indexed as

Alzheimer DiseaseAdenosineCell CycleHumansMethyltransferasesRNAAdenosineMethyltransferasesMETTL3 protein, humanRNAAberrant cell cycle eventsAlzheimer’s diseaseApoptosisMETTL3RNA m6A modificationRNA methylation

Identifiers

PMID34593014
PMCPMC8482683
OpenAlexW3204618747

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.