ArticleBMC biology2021
The genome of the zoonotic malaria parasite Plasmodium simium reveals adaptations to host switching.
Article in BMC biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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32 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- The threat of increased transmission of non-Parasitology · 2023Pooled it
- Genomic Insights Into Host Shifts BetweenEvolutionary applications · 2026Article
- Complete gene sequence diversity, amplification, and natural selection of the Plasmodium vivax Duffy binding protein locus.Malaria journal · 2025Article
- Novel zoonotic cases of Plasmodium simium from São Paulo with a reference genome of the Brazilian strain.Scientific reports · 2025Article
- Microbiome diversity in mosquitoes and sand flies: implications for vector competence.Parasites & vectors · 2025Review
- Molecular Screening ofAnimals : an open access journal from MDPI · 2025Article
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- Supersaturation mutagenesis reveals adaptive rewiring of essential genes among malaria parasites.Science (New York, N.Y.) · 2025Article
- An optimized transfer learning approach integrating deep convolutional feature extractors for malaria parasite classification in erythrocyte microscopy.Frontiers in medicine · 2025Article
- Autochthonous simian malaria in Brazil outside the Amazon: Emergence, zoonotic transmission and implications for disease control.One health (Amsterdam, Netherlands) · 2024Review
- Origin of the human malaria parasite Plasmodium vivax.Trends in parasitology · 2024Review
- Analytic Approaches in Genomic Epidemiological Studies of Parasitic Protozoa.Transboundary and emerging diseases · 2024Review
- Zoonotic Malaria Risk in Serra Do Mar, Atlantic Forest, Brazil.Microorganisms · 2023Article
- Detection of Plasmodium simium gametocytes in non-human primates from the Brazilian Atlantic Forest.Malaria journal · 2023Article
- NovelLancet regional health. Americas · 2023Article
- Malaria Detection Using Advanced Deep Learning Architecture.Sensors (Basel, Switzerland) · 2023Article
- Malaria and leishmaniasis: Updates on co-infection.Frontiers in immunology · 2023Review
- IgM antibody responses againstFrontiers in cellular and infection microbiology · 2023Article
- The first complete genome of the simian malaria parasite Plasmodium brasilianum.Scientific reports · 2022Article
- Is zoonotic Plasmodium vivax malaria an obstacle for disease elimination?Malaria journal · 2022Article
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Authors and funding
23 authors at 8 institutions in 5 countries.
Funding
Abstract
backgroundPlasmodium simium, a malaria parasite of non-human primates (NHP), was recently shown to cause zoonotic infections in humans in Brazil. We sequenced the P. simium genome to investigate its evolutionary history and to identify any genetic adaptions that may underlie the ability of this parasite to switch between host species.
resultsPhylogenetic analyses based on whole genome sequences of P. simium from humans and NHPs reveals that P. simium is monophyletic within the broader diversity of South American Plasmodium vivax, suggesting P. simium first infected NHPs as a result of a host switch of P. vivax from humans. The P. simium isolates show the closest relationship to Mexican P. vivax isolates. Analysis of erythrocyte invasion genes reveals differences between P. vivax and P. simium, including large deletions in the Duffy-binding protein 1 (DBP1) and reticulocyte-binding protein 2a genes of P. simium. Analysis of P. simium isolated from NHPs and humans revealed a deletion of 38 amino acids in DBP1 present in all human-derived isolates, whereas NHP isolates were multi-allelic.
conclusionsAnalysis of the P. simium genome confirmed a close phylogenetic relationship between P. simium and P. vivax, and suggests a very recent American origin for P. simium. The presence of the DBP1 deletion in all human-derived isolates tested suggests that this deletion, in combination with other genetic changes in P. simium, may facilitate the invasion of human red blood cells and may explain, at least in part, the basis of the recent zoonotic infections.
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