Evidence map›Paper›PMID 34592891›Full record

ArticleGut microbes

Hyaluronan-induced alterations of the gut microbiome protects mice against

Tangyou Mao, Chien-Wen Su, Qiaorong Ji, Chih-Yu Chen, Rongjun Wang, Deepak Vijaya Kumar, Jinggang Lan, Lefei Jiao, Hai Ning Shi

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Unveiling the Molecular Repertoire ofJournal of microbiology and biotechnology · 2026
    Review
  3. Microbe on the move:Journal of bacteriology · 2026
    Review
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  9. Postbiotic activity of Akkermansia muciniphila supernatant against antibiotic-resistant Enterococcus faecalis.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Tangyou MaoMucosal Immunology and Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, USA.
Chien-Wen SuMucosal Immunology and Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, USA.
Qiaorong JiMucosal Immunology and Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, USA.
Chih-Yu ChenLaboratory for Lipid Medicine and Technology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, USA.
Rongjun WangMucosal Immunology and Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, USA.
Deepak Vijaya KumarGenetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, USA.
Jinggang LanMucosal Immunology and Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, USA.
Lefei JiaoMucosal Immunology and Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, USA.
Hai Ning ShiMucosal Immunology and Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, USA.
Harvard University · USMassachusetts General Hospital · US

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
NIDDK NIH HHS P30 DK043351
6 · The paper itself

Abstract

Hyaluronan is a glycosaminoglycan polymer that has been shown to play an important role in homeostasis of the gastrointestinal tract. However, its mechanistic significance in gastrointestinal epithelial barrier elements remain unexplored. Here, our results revealed that hyaluronan treatment resulted in significant changes in the gut microbiota in mice. To demonstrate the functional consequences of hyaluronan-treatment and hyaluronan-induced microbiota alterations,

Indexed as

AnimalsBacteriaCitrobacter rodentiumColitisEnterobacteriaceae InfectionsFemaleGastrointestinal MicrobiomeHumansHyaluronic AcidIntestinal MucosaMiceMice, Inbred BALB CHyaluronic AcidAkkermansia muciniphilaCitrobacter rodentiumgut microbiomeHyaluronanintestinal inflammation

Identifiers

PMID34592891
PMCPMC8489935
OpenAlexW3202119635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.