Evidence map›Paper›PMID 34592883›Full record

ArticleVirulence2021

Unique virulence role of post-translocational chaperone PrsA in shaping

Zhao-Yi Wu, Anaamika Campeau, Chao-Hsien Liu, David J Gonzalez, Masaya Yamaguchi, Shigetada Kawabata, Chieh-Hsien Lu, Chian-Yu Lai, Hao-Chieh Chiu, Yung-Chi Chang

Open access · goldAbstract read
In one paragraph

Article in Virulence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Identification of immunostimulatory antigens in Group AProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Review
  3. The roles of theJournal of bacteriology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Zhao-Yi WuGraduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Anaamika CampeauDepartment of Pharmacology and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, CA, USA.
Chao-Hsien LiuGraduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan.
David J GonzalezDepartment of Pharmacology and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, CA, USA.
Masaya YamaguchiDepartment of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Japan.
Shigetada KawabataDepartment of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Japan.
Chieh-Hsien LuDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chian-Yu LaiGraduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Hao-Chieh ChiuDepartment of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Yung-Chi ChangGraduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan.ORCID 0000-0001-5153-0907
National Taiwan University · TWThe University of Osaka · JPUniversity of California San Diego · US

Funding

GRADUATE TRAINING IN CELLULAR &MOLECULAR PHARMACOLOGYT32GM007752 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, JOAN HELLER, HANDEL, TRACY M · 1985 to 2023
$13.5M
Rheumatic Diseases Research Training GrantT32AR064194 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GARY S FIRESTEIN, Monica Guma · 2013 to 2026
$3.8M
Contribution of the peptidome to CA-MRSA virulenceR01AI148417 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GONZALEZ, DAVID J · 2020 to 2024
$2.0M
Training Grant in Renal Function and DiseaseT32DK007752 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BELL, PHILLIP DARWIN · 1998 to 2013
$1.5M
Biomimetic Virulomics for Capture and Identification of Cell-Type Specific EffectorProteinsR21AI149090 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GONZALEZ, DAVID J · 2020 to 2021
$433k
NIAID NIH HHS R01 AI148417NIAID NIH HHS R21 AI149090NIAMS NIH HHS T32 AR064194NIDDK NIH HHS T32 DK007752NIGMS NIH HHS T32 GM007752
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Streptococcal InfectionsStreptococcus pyogenesAnimalsBacterial ProteinsHumansMiceMolecular ChaperonesProteomicsSecretomeVirulenceVirulence FactorsBacterial ProteinsMolecular ChaperonesVirulence FactorsParvulin-type peptidyl-prolyl isomerasePrsAsecretomeStreptococcus pyogenesvirulence

Identifiers

PMID34592883
PMCPMC8489961
OpenAlexW3202093817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.