Evidence map›Paper›PMID 34592739›Full record

ArticleCerebrovascular diseases extra2021

Attack Interval Is the Key to the Likely Pathogenesis of Multiple Transient Ischemic Attacks.

Yoshinari Nagakane, Tomoyuki Ohara, Eijirou Tanaka, Takehiro Yamada, Shinji Ashida, Yuta Kojima, Keiko Maezono, Shiori Ogura, Daisuke Nakashima, Takamasa Kitaoji and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebrovascular diseases extra, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Yoshinari NagakaneDepartment of Neurology, Kyoto Second Red Cross Hospital, Kyoto, Japan.
Tomoyuki OharaDepartment of Neurology, Kyoto Second Red Cross Hospital, Kyoto, Japan.
Eijirou TanakaDepartment of Neurology, Kyoto Second Red Cross Hospital, Kyoto, Japan.
Takehiro YamadaDepartment of Neurology, Kyoto Second Red Cross Hospital, Kyoto, Japan.
Shinji AshidaDepartment of Neurology, Kyoto Second Red Cross Hospital, Kyoto, Japan.
Yuta KojimaDepartment of Neurology, Kyoto Second Red Cross Hospital, Kyoto, Japan.
Keiko MaezonoDepartment of Neurology, Kyoto Second Red Cross Hospital, Kyoto, Japan.
Shiori OguraDepartment of Neurology, Kyoto Second Red Cross Hospital, Kyoto, Japan.
Daisuke NakashimaDepartment of Neurology, Kyoto Second Red Cross Hospital, Kyoto, Japan.
Takamasa KitaojiDepartment of Neurology, Kyoto Second Red Cross Hospital, Kyoto, Japan.
Yasumasa YamamotoDepartment of Neurology, Kyoto Second Red Cross Hospital, Kyoto, Japan.
Kyoto first Red Cross hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of this study was to test the hypothesis that the attack interval of multiple transient ischemic attacks (TIAs) is correlated with the underlying pathogenesis of ischemia.

methodsPatients with multiple TIAs, defined as 2 or more motor deficits within 7 days, were studied. The attack interval between the last 2 episodes was classified into 3 groups: 2 episodes within an hour (Hour group), over hours within a day (Day group), and over days within a week (Week group). Patients with a lacunar syndrome, no cortical lesions, and no embolic sources were recognized as having a small vessel disease (SVD) etiology for their multiple events.

resultsOf 312 TIA patients admitted over a 9-year period, 50 (37 males, 13 females, mean 67.6 years) had multiple TIAs. Twelve patients were classified as being within the Hour group, 23 within the Day group, and 15 within the Week group. Lacunar syndromes were observed in 30 (75%, 35%, and 67%), embolic sources were detected in 28 (25%, 65%, and 67%), and a high signal lesion on diffusion-weighted imaging was depicted in 30 (75%, 48%, and 67%) patients (18 cortical, 11 subcortical, and one cerebellar). Patients in the Hour group had a significantly higher prevalence of SVD etiology (75%) than those in the Day and Week groups (30%, p = 0.0165; 27%, p = 0.0213, respectively). Four patients had a subsequent stroke within 7 days.

conclusionAttack intervals of multiple TIAs may be correlated with the underlying pathogenesis of ischemia. Two motor deficits within an hour are more likely to suggest a SVD etiology.

Indexed as

Ischemic Attack, TransientStrokeDiffusion Magnetic Resonance ImagingFemaleHumansMaleCapsular warning syndromeSmall vessel diseaseStroke preventionTransient ischemic attack

Identifiers

PMID34592739
PMCPMC8543286
OpenAlexW3203454165

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.