ArticleNeurobiology of learning and memory2021
Optogenetic inhibition of either the anterior or posterior retrosplenial cortex disrupts retrieval of a trace, but not delay, fear memory.
Article in Neurobiology of learning and memory, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Differential modulation of aversive signaling by expectation across the cingulate cortex.bioRxiv : the preprint server for biology · 2026Article
- Reductions in protein degradation in the retrosplenial cortex regulate contextual fear memory formation in a sex-independent manner.Neurobiology of learning and memory · 2026Article
- Context controls the ability of unconditional stimulus deflation to mitigate fear relapse.Brain research · 2025Article
- Adolescent alcohol exposure disrupts extinction learning and retrosplenial cortex physiology in adult males.bioRxiv : the preprint server for biology · 2025Article
- Acquisition of trace fear conditioning without functional nucleus reuniens did not require dorsal or ventral hippocampus NMDA receptor activation in male Long-Evans rats.The international journal of neuropsychopharmacology · 2025Article
- The interval between conditional stimulus onset and unconditional stimulus onset, not training-to-test interval, determines patterns of immediate early gene expression in the anterior retrosplenial cortex.Neurobiology of learning and memory · 2025Article
- Psilocybin-enhanced fear extinction linked to bidirectional modulation of cortical ensembles.Nature neuroscience · 2025Article
- Behavioral outputs and overlapping circuits between conditional fear and active avoidance.Neurobiology of learning and memory · 2024Review
- Review
- Fear extinction is impaired in aged rats.GeroScience · 2024Article
- Psilocybin-enhanced fear extinction linked to bidirectional modulation of cortical ensembles.bioRxiv : the preprint server for biology · 2024Article
- Heterogenous effect of early adulthood stress on cognitive aging and synaptic function in the dentate gyrus.Frontiers in molecular neuroscience · 2024Article
- Generalization and discrimination of inhibitory avoidance differentially engage anterior and posterior retrosplenial subregions.Frontiers in behavioral neuroscience · 2024Article
- Retrosplenial cortex and aversive conditioning.Frontiers in behavioral neuroscience · 2024Review
- The clock gene Per1 is necessary in the retrosplenial cortex-but not in the suprachiasmatic nucleus-for incidental learning in young and aging male mice.Neurobiology of aging · 2023Article
- Unique roles for the anterior and posterior retrosplenial cortices in encoding and retrieval of memory for context.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Contributions of the rodent cingulate-retrosplenial cortical axis to associative learning and memory: A proposed circuit for persistent memory maintenance.Neuroscience and biobehavioral reviews · 2021Review
- Differential impacts of advanced age and sex in age-related trace fear memory impairment in rats.Learning & memory (Cold Spring Harbor, N.Y.)Article
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4 authors.
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Abstract
Previous work investigating the role of the retrosplenial cortex (RSC) in memory formation has demonstrated that its contributions are not uniform throughout the rostro-caudal axis. While the anterior region was necessary for encoding CS information in a trace conditioning procedure, the posterior retrosplenial cortex was needed to encode contextual information. Using the same behavioral procedure, we tested if there was a similar dissociation during memory retrieval. First, we found that memory retrieval following trace conditioning results in increased neural activity in both the anterior and posterior retrosplenial cortex, measured using the immediate early gene zif268. Similar increases were not found in either RSC subregion using a delay conditioning task. We then found that optogenetic inhibition of neural activity in either subregion impairs retrieval of a trace, but not delay, memory. Together these results add to a growing literature showing a role for the retrosplenial cortex in memory formation and retention. Further, they suggest that following formation, memory storage becomes distributed to a wider network than is needed for its initial consolidation.
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