Evidence map›Paper›PMID 34592217›Full record

ArticleJournal of molecular biology2021

Physiologically Relevant Free Ca

Brianna D Young, Kristen M Varney, Paul T Wilder, Brianna K Costabile, Edwin Pozharski, Mary E Cook, Raquel Godoy-Ruiz, Oliver B Clarke, Filippo Mancia, David J Weber

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Biomolecular NMR assignments · 2025
    Article
  3. Article
  4. Vitamin A supply in the eye and establishment of the visual cycle.Current topics in developmental biology · 2025
    Review
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Brianna D YoungThe Center for Biomolecular Therapeutics (CBT), Department of Biochemistry and Molecular Biology University of Maryland School of Medicine, 108 N. Greene St, Baltimore, MD 21201, USA.
Kristen M VarneyThe Center for Biomolecular Therapeutics (CBT), Department of Biochemistry and Molecular Biology University of Maryland School of Medicine, 108 N. Greene St, Baltimore, MD 21201, USA; The Institute of Bioscience and Biotechnology Research (IBBR), 9600 Gudelsky Dr., Rockville, MD 20850, USA.
Paul T WilderThe Center for Biomolecular Therapeutics (CBT), Department of Biochemistry and Molecular Biology University of Maryland School of Medicine, 108 N. Greene St, Baltimore, MD 21201, USA; The Institute of Bioscience and Biotechnology Research (IBBR), 9600 Gudelsky Dr., Rockville, MD 20850, USA.
Brianna K CostabileDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, USA.
Edwin PozharskiThe Center for Biomolecular Therapeutics (CBT), Department of Biochemistry and Molecular Biology University of Maryland School of Medicine, 108 N. Greene St, Baltimore, MD 21201, USA; The Institute of Bioscience and Biotechnology Research (IBBR), 9600 Gudelsky Dr., Rockville, MD 20850, USA.
Mary E CookThe Center for Biomolecular Therapeutics (CBT), Department of Biochemistry and Molecular Biology University of Maryland School of Medicine, 108 N. Greene St, Baltimore, MD 21201, USA.
Raquel Godoy-RuizThe Center for Biomolecular Therapeutics (CBT), Department of Biochemistry and Molecular Biology University of Maryland School of Medicine, 108 N. Greene St, Baltimore, MD 21201, USA; The Institute of Bioscience and Biotechnology Research (IBBR), 9600 Gudelsky Dr., Rockville, MD 20850, USA.
Oliver B ClarkeDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, USA.
Filippo ManciaDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, USA.
David J WeberThe Center for Biomolecular Therapeutics (CBT), Department of Biochemistry and Molecular Biology University of Maryland School of Medicine, 108 N. Greene St, Baltimore, MD 21201, USA; The Institute of Bioscience and Biotechnology Research (IBBR), 9600 Gudelsky Dr., Rockville, MD 20850, USA. Electronic address: DWeber@som.umaryland.edu.
University of Maryland, Baltimore · USColumbia University · USInstitute for Bioscience and Biotechnology Research

Funding

Interdisciplinary Training Program Muscle BiologyT32AR007592 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI Aikaterini Kontrogianni-Konstantopoulos · 1996 to 2026
$11.7M
Structural basis of receptor-mediated cellular vitamin A uptakeR01EY027405 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI George Khelashvili, Filippo Mancia · 2017 to 2026
$4.4M
Signal Propagation in Protein Allostery: Mechanism and EvolutionR01GM129327 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI WEBER, DAVID JOSEPH · 2019 to 2022
$1.3M
NEI NIH HHS R01 EY027405NIAMS NIH HHS T32 AR007592NIGMS NIH HHS R01 GM129327
6 · The paper itself

Abstract

The interaction of calmodulin (CaM) with the receptor for retinol uptake, STRA6, involves an α-helix termed BP2 that is located on the intracellular side of this homodimeric transporter (Chen et al., 2016 [1]). In the absence of Ca

Indexed as

CalciumCalmodulinEF Hand MotifsHumansMagnetic Resonance SpectroscopyMembrane Transport ProteinsMultiprotein ComplexesPeptide FragmentsProtein ConformationRecombinant ProteinsSpectrometry, FluorescenceThermodynamicsVitamin AZebrafish ProteinsCalciumCalmodulinMembrane Transport ProteinsMultiprotein ComplexesPeptide FragmentsRecombinant ProteinsSTRA6 protein, zebrafishVitamin AZebrafish Proteinscalmodulinretinolretinol-binding proteinSTRA6vitamin A receptor

Identifiers

PMID34592217
PMCPMC8568335
OpenAlexW3202938810

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.