Evidence map›Paper›PMID 34592146›Full record

ArticleCell reports2021

Vitamin B

Andy B Lam, Kirsten Kervin, Jessica E Tanis

Abstract read
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Genome-wide meta-analysis identifies ancestry-specific loci for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Vitamin BNature communications · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Vitamin BResearch square · 2025
    Article
  11. Review
  12. Nutrition: A non-negligible factor in the pathogenesis and treatment of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. PMGut microbes · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Andy B LamDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
Kirsten KervinDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
Jessica E TanisDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA. Electronic address: jtanis@udel.edu.

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI MELINDA K DUNCAN · 2012 to 2026
$67.2M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
NIGMS NIH HHS P20 GM103446NIH HHS P40 OD010440
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a devastating neurodegenerative disorder with no effective treatment. Diet, as a modifiable risk factor for AD, could potentially be targeted to slow disease onset and progression. However, complexity of the human diet and indirect effects of the microbiome make it challenging to identify protective nutrients. Multiple factors contribute to AD pathogenesis, including amyloid beta (Aβ) deposition, energy crisis, and oxidative stress. Here, we use Caenorhabditis elegans to define the impact of diet on Aβ proteotoxicity. We discover that dietary vitamin B

Indexed as

5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseAmyloid beta-PeptidesAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsMethionineOxidative StressS-AdenosylmethionineVitamin B 12Vitamins5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseAmyloid beta-PeptidesCaenorhabditis elegans ProteinsMethionineS-AdenosylmethionineVitamin B 12VitaminsAlzheimer’s diseaseamyloid betaATPC. eleganscholinedietmethionineS-adenosylmethioninevitamin B(12)

Identifiers

PMID34592146
PMCPMC8522492

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.