ArticlePLoS biology2021
Mathematical learning deficits originate in early childhood from atypical development of a frontoparietal brain network.
Article in PLoS biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 26 citations in OpenAlex.
- Grammar acquisition in preschool children is related to white matter maturation of the dorsal language network.Developmental cognitive neuroscience · 2026Article
- Lesion-symptom mapping reveals differential relationships between language and precise versus approximate numeracy.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Children identified for classroom-based math support show altered resting-state connectivity in parietal brain regions.Scientific reports · 2025Article
- From brain to education through machine learning: Predicting literacy and numeracy skills from neuroimaging data.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Changes in the superior longitudinal fasciculus and anterior thalamic radiation in the left brain are associated with developmental dyscalculia.Frontiers in human neuroscience · 2023Article
- Neurocognitive mechanisms underlying multiplication and subtraction performance in adults and skill development in children: A scoping review.Current opinion in behavioral sciences · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mathematical learning deficits are defined as a neurodevelopmental disorder (dyscalculia) in the International Classification of Diseases. It is not known, however, how such deficits emerge in the course of early brain development. Here, we conducted functional and structural magnetic resonance imaging (MRI) experiments in 3- to 6-year-old children without formal mathematical learning experience. We followed this sample until the age of 7 to 9 years, identified individuals who developed deficits, and matched them to a typically developing control group using comprehensive behavioral assessments. Multivariate pattern classification distinguished future cases from controls with up to 87% accuracy based on the regional functional activity of the right posterior parietal cortex (PPC), the network-level functional activity of the right dorsolateral prefrontal cortex (DLPFC), and the effective functional and structural connectivity of these regions. Our results indicate that mathematical learning deficits originate from atypical development of a frontoparietal network that is already detectable in early childhood.
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