ArticleAging2021
Downregulation of KIF2C and TEKT2 is associated with male infertility and testicular carcinoma.
Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Brief biology and pathophysiology of Tekt bundles.Cell adhesion & migration · 2025Review
- PCM1 orchestrates centrosomal and flagellar protein transport to promote sperm maturation.Communications biology · 2025Article
- Clonal dispersal is associated with tumor heterogeneity and poor prognosis in colorectal cancer.iScience · 2025Article
- KIF2C is essential for meiosis and manchette dynamics in male mice.Frontiers in cell and developmental biology · 2025Article
- Article
- Lymph node metastasis-related gene signature shows good performance in predicting prognosis and immune infiltration in cervical cancer.Frontiers in oncology · 2023Article
- An in-silico approach leads to explore six genes as a molecular signatures of lung adenocarcinoma.American journal of cancer research · 2023Article
- Kinesins in Mammalian Spermatogenesis and Germ Cell Transport.Frontiers in cell and developmental biology · 2022Review
- Aberrant Gene Expression Profiling in Men With Sertoli Cell-Only Syndrome.Frontiers in immunology · 2022Article
- KIF2C Deletion Causes Meiotic Abnormalities and Nonobstructive Azoospermia in Mice.Reproductive medicine and biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenetic factors are important in spermatogenesis and fertility maintenance, and are potentially significant biomarkers for the early detection of infertility. However, further understanding of these biological processes is required.
methodsIn the present study, we sought to identify associated genes by reanalyzing separate studies from Gene Expression Omnibus datasets (GSE45885, GSE45887 and GSE9210) and validation datasets (GSE4797, 145467, 108886, 6872). The differential genes were used the limma package in R language. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed by the clusterprofier package. The protein-protein interaction network was constructed by the STRING database. The interaction between mRNA and TF was predicted by miRWalk web. At last, The Cancer Genome Atlas data were used to identify hub gene expression levels in GEPIA web.
resultsThe results showed that 27 shared genes associated with spermatogenesis. We effectively screen out two genes (KIF2C and TEKT2) and both validated by GSE4797, 145467, 108886 and 6872. Among 27 shared genes, KIF2C and TEKT2 both down-regulated in spermatogenesis. The network of TF-miRNA-target gene was established, we found KIF2C-miRNAs (has-miR-3154, 6075, 6760-5p, 1251-5p, 186-sp)-TFs (EP300, SP1) might work in spermatogenesis.
conclusionsOur study might help to improve our understanding of the mechanisms in spermatogenesis and provide diagnostic biomarkers and therapeutics targets.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.