Evidence map›Paper›PMID 34591766›Full record

ArticleIEEE transactions on visualization and computer graphics2022

THALIS: Human-Machine Analysis of Longitudinal Symptoms in Cancer Therapy.

Carla Floricel, Nafiul Nipu, Mikayla Biggs, Andrew Wentzel, Guadalupe Canahuate, Lisanne Van Dijk, Abdallah Mohamed, C David Fuller, G Elisabeta Marai

Abstract read
In one paragraph

Article in IEEE transactions on visualization and computer graphics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Improving Survival Prediction of Head and Neck Cancer Patients by Modeling Long-term Symptom Burden.Proceedings. IEEE International Conference on Healthcare Informatics · 2026
    Article
  3. L-VISP: LSTM Visualization for Interpretable Symptom Prediction in Patient Cohorts.Computer graphics forum : journal of the European Association for Computer Graphics · 2026
    Article
  4. Lessons from the Development and Deployment of an Interactive Oncological Risk Estimator.... IEEE Workshop on Visual Analytics in Healthcare. IEEE Workshop on Visual Analytics in Healthcare · 2025
    Article
  5. FlavorCharter: Development of a Smartphone App for Quantifying Food Flavor.Proceedings ... ICDM workshops. IEEE International Conference on Data Mining · 2025
    Article
  6. mEnergy: Development of a Novel mHealth Multi-device Platform for Near Real-time Remote Assessment of Energy Disorders.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025
    Article
  7. Article
  8. Article
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  11. Article
  12. Article
  13. DASS Good: Explainable Data Mining of Spatial Cohort Data.Computer graphics forum : journal of the European Association for Computer Graphics · 2023
    Article
  14. Visual Analysis and Detection of Contrails in Aircraft Engine Simulations.IEEE transactions on visualization and computer graphics · 2023
    Article
  15. Article
  16. A Tale of Two Centers: Visual Exploration of Health Disparities in Cancer Care.IEEE Pacific Visualization Symposium : [proceedings]. IEEE Pacific Visualisation Symposium · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carla Floricel
Nafiul Nipu
Mikayla Biggs
Andrew Wentzel
Guadalupe Canahuate
Lisanne Van Dijk
Abdallah Mohamed
C David Fuller
G Elisabeta Marai

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
Longitudinal Spatial-Nonspatial Decision Support for Competing Outcomes in Head and Neck Cancer TherapyR01CA258827 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CANAHUATE, GUADALUPE, FULLER, CLIFTON DAVID · 2021 to 2025
$2.9M
Development of novel protein-based therapeutics for lung cancerR01CA225103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BASSIK, MICHAEL C, COCHRAN, JENNIFER R · 2018 to 2022
$2.8M
Uncovering Clinical Evidence in COVID-19 Publications: An Integrated Search via Text & ImagesR01LM012527 · NLM · UNIVERSITY OF DELAWARE · PI EIGENMANN, RUDOLF, MARAI, GEORGETA-ELISABETA · 2017 to 2020
$1.9M
SMART-ACT: Spatial Methodologic Approaches for Risk Assessment and Therapeutic Adaptation in Cancer TreatmentR01CA214825 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CANAHUATE, GUADALUPE, FULLER, CLIFTON DAVID · 2017 to 2019
$1.1M
NCI NIH HHS R01 CA214825NCI NIH HHS R01 CA225103NCI NIH HHS R01 CA258827NLM NIH HHS R01 LM012527
6 · The paper itself

Abstract

Although cancer patients survive years after oncologic therapy, they are plagued with long-lasting or permanent residual symptoms, whose severity, rate of development, and resolution after treatment vary largely between survivors. The analysis and interpretation of symptoms is complicated by their partial co-occurrence, variability across populations and across time, and, in the case of cancers that use radiotherapy, by further symptom dependency on the tumor location and prescribed treatment. We describe THALIS, an environment for visual analysis and knowledge discovery from cancer therapy symptom data, developed in close collaboration with oncology experts. Our approach leverages unsupervised machine learning methodology over cohorts of patients, and, in conjunction with custom visual encodings and interactions, provides context for new patients based on patients with similar diagnostic features and symptom evolution. We evaluate this approach on data collected from a cohort of head and neck cancer patients. Feedback from our clinician collaborators indicates that THALIS supports knowledge discovery beyond the limits of machines or humans alone, and that it serves as a valuable tool in both the clinic and symptom research.

Indexed as

Computer GraphicsHead and Neck NeoplasmsHumans

Identifiers

PMID34591766
PMCPMC8785360

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.