ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2021
Inosine monophosphate and inosine differentially regulate endotoxemia and bacterial sepsis.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 37 citations in OpenAlex.
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- Investigation of the effects and underlying mechanisms of adenylate kinase 1 on inosine monophosphate deposition in Beijing-You chickens.Poultry science · 2026Article
- Immune Regulatory and Underlying Mechanisms of Polysaccharides fromMolecules (Basel, Switzerland) · 2026Article
- Age-Associated Metabolomic Changes in Human Spermatozoa.International journal of molecular sciences · 2026Article
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- Nucleotide Metabolic Reprogramming in Sepsis: From Immune-Cell Fate to Organ Injury and Precision Therapeutics.Journal of inflammation research · 2026Review
- Alterations in nutrient availability in the lungs duringInfection and immunity · 2025Article
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- Cold-water immersion alleviates intestinal damage induced by exertional heat stroke via modulation of gut microbiota in rats.Frontiers in microbiomes · 2025Article
- Therapeutic potential of L-Carnitine in improving adenine-induced hematological abnormalities in rats: A preclinical pharmacological study.Open veterinary journal · 2025Article
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- Shotgun metagenomic analysis of the oral microbiome in gingivitis: a nested case-control study.Journal of oral microbiology · 2024Article
- Multikingdom oral microbiome interactions in early-onset cryptogenic ischemic stroke.ISME communications · 2024Article
- Anomalous Dynamics of Labile Metabolites in Cold Human Blood Detected UsingAnalytical chemistry · 2023Article
- Resveratrol Mitigates Metabolism in Human Microglia Cells.Antioxidants (Basel, Switzerland) · 2023Article
- Integrative transcriptomic and metabolomic analysis reveals alterations in energy metabolism and mitochondrial functionality in broiler chickens with wooden breast.Scientific reports · 2023Article
- Investigating the renoprotective effect of C21 in male mice with sepsis via modulation of p-AKT/PI3K expression.Journal of medicine and life · 2023Article
- UPLC-Q-TOF/MS-Based Metabolomics Approach Reveals Osthole Intervention in Breast Cancer 4T1 Cells.International journal of molecular sciences · 2023Article
- Inosine: A broad-spectrum anti-inflammatory against SARS-CoV-2 infection-induced acute lung injury via suppressing TBK1 phosphorylation.Journal of pharmaceutical analysis · 2023Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Inosine monophosphate (IMP) is the intracellular precursor for both adenosine monophosphate and guanosine monophosphate and thus plays a central role in intracellular purine metabolism. IMP can also serve as an extracellular signaling molecule, and can regulate diverse processes such as taste sensation, neutrophil function, and ischemia-reperfusion injury. How IMP regulates inflammation induced by bacterial products or bacteria is unknown. In this study, we demonstrate that IMP suppressed tumor necrosis factor (TNF)-α production and augmented IL-10 production in endotoxemic mice. IMP exerted its effects through metabolism to inosine, as IMP only suppressed TNF-α following its CD73-mediated degradation to inosine in lipopolysaccharide-activated macrophages. Studies with gene targeted mice and pharmacological antagonism indicated that A
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