Evidence map›Paper›PMID 34591311›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Quantification of In Vitro Blood-Brain Barrier Permeability.

Bingmei M Fu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Transport Across the Blood-Brain Barrier.Advances in experimental medicine and biology · 2026
    Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Bingmei M FuDepartment of Biomedical Engineering, The City College of the City University of New York, New York, NY, USA. fu@ccny.cuny.edu.

Funding

Integrated Microphysiological System of Cerebral Organoid and Blood Vessel for Disease Modeling and Neuropsychiatric Drug screeningUH3TR002151 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEONG, KAM W · 2020 to 2022
$3.6M
Integrated Microphysiological System of Cerebral Organoid and Blood Vessel for Disease Modeling and Neuropsychiatric Drug screeningUG3TR002151 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEONG, KAM W · 2018 to 2019
$2.6M
NCATS NIH HHS UG3 TR002151NCATS NIH HHS UH3 TR002151
6 · The paper itself

Abstract

In vitro blood-brain barrier (BBB) models have been widely used to simulate in vivo models due to their low cost, feasibility, and repeatability. To serve as a valid substitute, the in vitro BBB should have the similar barrier function as that in vivo. This chapter summarizes the detailed methods for quantifying the barrier function, e.g., the permeability of the BBB to water, ions, and solutes for an in vitro BBB generated on the Transwell filter.

Indexed as

Blood-Brain BarrierBiological TransportCapillary PermeabilityPermeabilityDiffusive solute permeabilityHydraulic conductivityIn vitro blood-brain barrierTrans-BBB electric resistance (TER )Transwell filter

Identifiers

PMID34591311
PMCPMC12208173

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.