ArticleMethods in molecular biology (Clifton, N.J.)2022
Fabrication and Evaluation of Tissue-Engineered Vascular Grafts with Hybrid Fibrous Structure.
Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Bypass surgery has proven to be an effective strategy for the treatment of cardiovascular diseases. In this chapter, we describe the preparation of a type of small-diameter vascular grafts with hybrid fibrous structure by co-electrospinning. Of the two components, slow-degrading poly(ε-caprolactone) (PCL) fibers maintain the structural integrity of the graft and provide sufficient mechanical strength. The other component is rapidly degradable polymer polydioxanone (PDS) or type-I collagen that can be used as a carrier to deliver vasoactive molecules at the same time. The in vivo performance of as-prepared vascular grafts was further evaluated in a rat abdominal aorta replacement model.
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