Evidence map›Paper›PMID 34591299›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Microfluidic Coaxial Bioprinting of Hollow, Standalone, and Perfusable Vascular Conduits.

Sushila Maharjan, Jacqueline Jialu He, Li Lv, Di Wang, Yu Shrike Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sushila MaharjanDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA.
Jacqueline Jialu HeDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA.
Li LvDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA.
Di WangDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA.
Yu Shrike ZhangDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA. yszhang@research.bwh.harvard.edu.
Brigham and Women's Hospital · USHarvard University · US

Funding

Stretchable Hydrogel Bioinks-Enabled Microfluidic Bioprinting of Functional Small-Diameter Blood VesselsR01HL153857 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ZHAO, XUANHE · 2020 to 2024
$2.4M
High-Throughput Volumetric Photoacoustic Imaging of Living Vascularized OrganoidsR01EB028143 · NIBIB · DUKE UNIVERSITY · PI YAO, JUNJIE · 2019 to 2022
$2.0M
Recapitulating Ductal Carcinoma on a Chip for Personalized Breast Cancer TherapyR00CA201603 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHANG, Y. SHRIKE · 2019 to 2021
$747k
Multiscale Stereolithogrphic Bioprinting of Stage-Matching Vascularized Tumor ModelsR21EB025270 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHANG, Y. SHRIKE · 2018 to 2020
$726k
Development of An Optoelectronically Active BioinkR21EB030257 · NIBIB · UNIVERSITY OF HOUSTON · PI YU, CUNJIANG · 2020 to 2020
$694k
Developing Hybrids of Cardiac Tissue and Biodegradable Electronics Towards Heart Implants with On-line Monitoring and Stimulating FunctionsR21EB026175 · NIBIB · UNIVERSITY OF HOUSTON · PI YU, CUNJIANG · 2018 to 2019
$468k
NCI NIH HHS R00 CA201603NHLBI NIH HHS R01 HL153857NIBIB NIH HHS R01 EB028143NIBIB NIH HHS R21 EB025270NIBIB NIH HHS R21 EB026175NIBIB NIH HHS R21 EB030257
6 · The paper itself

Abstract

Three-dimensional bioprinting represents promising approach for fabricating standalone and perfusable vascular conduits using biocompatible materials. Here we describe a step-by-step method by using a multichannel coaxial extrusion system (MCCES) and a blend bioink constituting gelatin methacryloyl, sodium alginate, and eight-arm poly(ethylene glycol)-acrylate with a tripentaerythritol core for the fabrication of standalone circumferentially multilayered hollow tubes. This microfluidic bioprinting method allows the fabrication of perfusable vascular conduits with a core lumen, an inner endothelial layer resembling the tunica intima, and an outer smooth muscle cell layer resembling the tunica media of the blood vessel. Biocompatible and perfusable blood vessels with a widely tunable size range in terms of luminal diameters and wall thicknesses can be successfully fabricated using the MCCES.

Indexed as

BioprintingGelatinMethacrylatesMicrofluidicsPrinting, Three-DimensionalTissue EngineeringTissue ScaffoldsGelatingelatin methacryloylMethacrylatesEight-arm poly(ethylene glycol)-acrylate with a tripentaerythritol coreEndothelial cellsGelatin methacryloylLumenMicrofluidic bioprintingMultichannel coaxial extrusion systemSmooth muscle cellsSodium alginateVascular conduits

Identifiers

PMID34591299
OpenAlexW3203356581

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.