ArticleClinical and experimental nephrology2022
Creatinine generation rate can detect sarcopenia in patients with hemodialysis.
Article in Clinical and experimental nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 21 citations in OpenAlex.
- Muscle Quality Assessed by the Phase Angle Can Predict Renal Prognosis in Patients with Chronic Kidney Disease.Journal of clinical medicine · 2025Article
- Longitudinal impact of extended-hours hemodialysis with a liberalized diet on nutritional status and survival outcomes: findings from the LIBERTY cohort.Clinical and experimental nephrology · 2025Article
- Article
- Managing Dosage Adjustments in Pseudo-Hypocreatinemia: Insights from Vancomycin-Induced Nephrotoxicity in a Sarcopenic Patient.Yonago acta medica · 2024Article
- Superiority of high sensitivity cardiac troponin I over NT-proBNP and adiponectin for 7-year mortality in stable patients receiving haemodialysis.Scientific reports · 2024Article
- Development and validation of a nomogram model for predicting low muscle mass in patients undergoing hemodialysis.Renal failure · 2023Article
- Recent Advances in the Nutritional Screening, Assessment, and Treatment of Japanese Patients on Hemodialysis.Journal of clinical medicine · 2023Article
- Use machine learning to help identify possible sarcopenia cases in maintenance hemodialysis patients.BMC nephrology · 2023Article
- Gender Disparity in Expression of Sarcopenia in Haemodialysis Recipients: Analysis from the FITNESS Cohort.International journal of nephrology · 2023Article
- Association of the modified creatinine index with muscle strength and mortality in patients undergoing hemodialysis.Renal failure · 2022Article
- Development of a Practical Screening Tool to Predict Sarcopenia in Patients on Maintenance Hemodialysis.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Comparison of the predictability of serum creatinine-based surrogates of skeletal muscle mass for all-cause mortality in patients receiving hemodialysis: creatinine generation rate and creatinine index.Clinical and experimental nephrology · 2022Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSarcopenia is strongly associated with long-term mortality in patients undergoing hemodialysis. The diagnostic modalities used to assess muscle mass, such as bioimpedance analysis and dual-energy X-ray absorption measurement, have limitations for application in patients on hemodialysis. Therefore, there is a need to establish a simple index for assessing muscle mass that can be universally performed in patients on hemodialysis.
methodsPatients on maintenance hemodialysis were included in this study. Laboratory tests, skeletal muscle mass measured by bioimpedance analysis, and clinical records were obtained retrospectively. The creatinine generation rate (CGR) was calculated from the pre- and postdialysis blood tests using a kinetic model as the index for whole-body muscle mass. Correlations between the CGR and skeletal muscle mass were investigated, and the cut-off value for muscle wasting was determined. Kaplan-Meier survival analysis was performed to investigate the feasibility of the CGR for predicting long-term survival.
resultsAmong the 130 patients included, eight were diagnosed with sarcopenia by bioimpedance analysis. The CGR was positively correlated with skeletal muscle mass (r = 0.454, p < 0.001). Multiple linear regression analysis revealed that age and sex independently influenced the CGR. The patients were classified into two groups according to age- and sex-adjusted CGRs. During a median follow-up period of 32 months, the Kaplan-Meier survival analysis showed that patients with low CGR showed significantly poor long-term prognosis (p = 0.002).
conclusionThe CGR is a simple index for muscle mass and can predict long-term mortality in patients on hemodialysis.
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