Evidence map›Paper›PMID 34591046›Full record

ArticleBiomaterials science2021

The

Christian Isalomboto Nkanga, Young Hun Chung, Sourabh Shukla, Jingcheng Zhou, Jesse V Jokerst, Nicole F Steinmetz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Christian Isalomboto NkangaDepartment of NanoEngineering, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92039, USA. nsteinmetz@ucsd.edu.ORCID http://orcid.org/0000-0001-7712-478X
Young Hun ChungDepartment of Bioengineering, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92039, USA.ORCID http://orcid.org/0000-0002-6578-8076
Sourabh ShuklaDepartment of NanoEngineering, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92039, USA. nsteinmetz@ucsd.edu.ORCID http://orcid.org/0000-0001-9751-5833
Jingcheng ZhouDepartment of NanoEngineering, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92039, USA. nsteinmetz@ucsd.edu.
Jesse V JokerstDepartment of NanoEngineering, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92039, USA. nsteinmetz@ucsd.edu.ORCID http://orcid.org/0000-0003-2829-6408
Nicole F SteinmetzDepartment of NanoEngineering, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92039, USA. nsteinmetz@ucsd.edu.ORCID http://orcid.org/0000-0002-0130-0481
University of California San Diego · US

Funding

Therapeutic Drug Monitoring with a Wearable Ultrasound-based SensorDP2HL137187 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOKERST, JESSE VINCENT · 2016 to 2019
$2.7M
Diagnosis and longitudinal monitoring of metastatic prostate cancer through molecular MR imaging.R01CA202814 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI STEINMETZ, NICOLE FRANZISKA · 2016 to 2020
$2.0M
Vevo LAZR Photoacoustic Imaging SystemS10OD021821 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HALL, DAVID J · 2016 to 2016
$594k
NCI NIH HHS R01 CA202814NHLBI NIH HHS DP2 HL137187NIH HHS S10 OD021821
6 · The paper itself

Abstract

Plant virus nanoparticles (VNPs) have multiple advantages over their synthetic counterparts including the cost-effective large-scale manufacturing of uniform particles that are easy to functionalize. Tobacco mosaic virus (TMV) is one of the most promising VNP scaffolds, reflecting its high aspect ratio and ability to carry and/or display multivalent therapeutic ligands and contrast agents. Here we investigated the circulation, protein corona, immunogenicity, and organ distribution/clearance of TMV particles internally co-labeled with cyanine 5 (Cy5) and chelated gadolinium (Gd) for dual tracking by fluorescence imaging and optical emission spectrometry, with or without an external coating of polydopamine (PDA) to confer photothermal and photoacoustic capabilities. The PDA-coated particles (Gd-Cy5-TMV-PDA) showed a shorter plasma circulation time and broader distribution to organs of the reticuloendothelial system (liver, lungs, and spleen) than uncoated Gd-Cy5-TMV particles (liver and spleen only). The Gd-Cy5-TMV-PDA particles were surrounded by 2-10-fold greater protein corona (containing mainly immunoglobulins) compared to Gd-Cy5-TMV particles. However, the enzyme-linked immunosorbent assay (ELISA) revealed that PDA-coated particles bind 2-fold lesser to anti-TMV antibodies elicited by particle injection than uncoated particles, suggesting that the PDA coat enables evasion from systemic antibody surveillance. Gd-Cy5-TMV-PDA particles were cleared from organs after 8 days compared to 5 days for the uncoated particles. The slower tissue clearance of the coated particles makes them ideal for theranostic applications by facilitating sustained local delivery in addition to multimodal imaging and photothermal capabilities. We have demonstrated the potential of PDA-coated proteinaceous nanoparticles for multiple biomedical applications.

Indexed as

NanoparticlesTobacco Mosaic VirusIndolesPolymersPrecision MedicineIndolespolydopaminePolymers

Identifiers

PMID34591046
PMCPMC8600448
OpenAlexW3203095686

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.