Evidence map›Paper›PMID 34591012›Full record

ArticleeLife2021

Adaptation and compensation in a bacterial gene regulatory network evolving under antibiotic selection.

Vishwa Patel, Nishad Matange

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
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  4. Vitamin BCommunications biology · 2025
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  7. Review
  8. The virulence regulatorJournal of bacteriology · 2025
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  9. Article
  10. Analysis of stress-induced small proteins inbioRxiv : the preprint server for biology · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Grow now, pay later: When should a bacterium go into debt?Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Vishwa PatelDr. Vikram Sarabhai Institute of Cell and Molecular Biology, The Maharaja Sayajirao University of Baroda, Vadodara, India.
Nishad MatangeIndian Institute of Science Education and Research (IISER), Pune, India.ORCID 0000-0002-2947-3931
Indian Institute of Science Education and Research Kolkata · INMaharaja Sayajirao University of Baroda · IN

Funding

DBT-Wellcome Trust India Alliance IA/I/20/2/505181Wellcome Trust
6 · The paper itself

Abstract

Gene regulatory networks allow organisms to generate coordinated responses to environmental challenges. In bacteria, regulatory networks are re-wired and re-purposed during evolution, though the relationship between selection pressures and evolutionary change is poorly understood. In this study, we discover that the early evolutionary response of

Indexed as

Genes, BacterialAnti-Bacterial AgentsDrug Resistance, BacterialEscherichia coliEscherichia coli ProteinsEvolution, MolecularGene Regulatory NetworksMutationTetrahydrofolate DehydrogenaseTrimethoprimAnti-Bacterial AgentsEscherichia coli ProteinsTetrahydrofolate DehydrogenaseTrimethoprimanti-microbial resistancecompensatory evolutionE. coliexperimental evolutiongene regulatory networksgeneticsgenomicsinfectious diseaseMgrBmicrobiologytrimethoprim

Identifiers

PMID34591012
PMCPMC8483737
OpenAlexW3203917691

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.