Evidence map›Paper›PMID 34590912›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2021

Exercise prevents whole body type 2 diabetes risk factors better than estradiol replacement in rats.

Luke J Fritsch, Skylar J McCaulley, Colton R Johnson, Nicholaus J Lawson, Brittany K Gorres-Martens

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Luke J FritschBiology Department, Augustana University, Sioux Falls, South Dakota.
Skylar J McCaulleyBiology Department, University of Sioux Falls, Sioux Falls, South Dakota.
Colton R JohnsonExercise Science Department, University of Sioux Falls, Sioux Falls, South Dakota.
Nicholaus J LawsonExercise Science Department, University of Sioux Falls, Sioux Falls, South Dakota.
Brittany K Gorres-MartensExercise and Sport Sciences Department, Augustana University, Sioux Falls, South Dakota.ORCID 0000-0001-8100-0624
University of Sioux Falls · USAugustana University · US

Funding

Wichozani-A Healthy Lifestyle for Rural American Indian Youth through Cultural and Physical Activities: A Community-Based Participatory Research StudyP20GM103443 · NIGMS · UNIVERSITY OF SOUTH DAKOTA · PI Ryan Michael Johnson · 2012 to 2026
$58.1M
NIGMS NIH HHS P20 GM103443NIGMS NIH HHS P20GM103443
6 · The paper itself

Abstract

The absence of estrogens in postmenopausal women is linked to an increased risk of type 2 diabetes (T2D) and estradiol replacement can decrease this risk. Notably, exercise can also treat and prevent T2D. This study seeks to understand the molecular mechanisms by which estradiol and exercise induce their beneficial effects via assessing whole body and cellular changes. Female Wistar rats were ovariectomized and fed a high-fat diet for 10 wk and divided into the following four experimental groups:

Indexed as

Diabetes Mellitus, Type 2EstradiolAdipose TissueAdipose Tissue, WhiteAnimalsBody WeightFemaleLiverRatsRats, WistarRisk FactorsEstradiolestradiolfat metabolismhigh-fat dietprescribed exercise

Identifiers

PMID34590912
PMCPMC8616605
OpenAlexW3204400222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.