Evidence map›Paper›PMID 34590907›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2021

Intravital assessment of precapillary pulmonary arterioles of type 1 diabetic mice shows oxidative damage and increased tone in response to NOS inhibition.

Andrew M Roberts, Nayeem Z Moulana, Rekha Jagadapillai, Lu Cai, Evelyne Gozal

Abstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Assessments of microvascular function in organ systems.American journal of physiology. Heart and circulatory physiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Andrew M RobertsDepartment of Physiology, University of Louisville School of Medicine, Louisville, Kentucky.ORCID 0000-0003-4604-5135
Nayeem Z MoulanaDepartment of Physiology, University of Louisville School of Medicine, Louisville, Kentucky.
Rekha JagadapillaiDepartment of Pediatrics, Pediatric Research Institute, University of Louisville School of Medicine, Louisville, Kentucky.
Lu CaiDepartment of Pediatrics, Pediatric Research Institute, University of Louisville School of Medicine, Louisville, Kentucky.ORCID 0000-0003-3048-1135
Evelyne GozalDepartment of Physiology, University of Louisville School of Medicine, Louisville, Kentucky.
University of Louisville · US

Funding

University of Louisville Center for Integrative Environmental Health SciencesP30ES030283 · NIEHS · UNIVERSITY OF LOUISVILLE · PI Amanda Jo LeBlanc · 2020 to 2026
$10.0M
NIEHS NIH HHS P30 ES030283
6 · The paper itself

Abstract

Microvascular dilation, important for peripheral tissue glucose distribution, also modulates alveolar perfusion and is inhibited by loss of bioavailable nitric oxide (NO) in diabetes mellitus (DM). We hypothesized that DM-induced oxidative stress decreases bioavailable NO and pulmonary precapillary arteriolar diameter, causing endothelial injury. We examined subpleural pulmonary arterioles after acute NO synthase (NOS) inhibition with

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1AnimalsArteriolesLungMiceMice, Inbred C57BLNG-Nitroarginine Methyl EsterNitric OxideOxidative StressVasodilationNG-Nitroarginine Methyl EsterNitric Oxidearteriolar dysfunctiondiabetesoxidative stresspulmonary microcirculation

Identifiers

PMID34590907
PMCPMC11961051
OpenAlexW3202378053

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.