Evidence map›Paper›PMID 34590824›Full record

ArticleACS chemical biology2021

Genetic Incorporation of Two Mutually Orthogonal Bioorthogonal Amino Acids That Enable Efficient Protein Dual-Labeling in Cells.

Riley M Bednar, Subhashis Jana, Sahiti Kuppa, Rachel Franklin, Joseph Beckman, Edwin Antony, Richard B Cooley, Ryan A Mehl

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Bioorthogonal Reactions in Bioimaging.Topics in current chemistry (Cham) · 2024
    Review
  14. Article
  15. Article
  16. Glutathione Mediates Control of Dual Differential Bio-orthogonal Labelling of Biomolecules.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2023
    Article
  17. Fluorescent human RPA to track assembly dynamics on DNA.bioRxiv : the preprint server for biology · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Riley M BednarDepartment of Biochemistry and Biophysics, Oregon State University, 2011 Agricultural & Life Sciences Building, Corvallis, Oregon 97331-7305, United States.ORCID 0000-0001-9452-825X
Subhashis JanaDepartment of Biochemistry and Biophysics, Oregon State University, 2011 Agricultural & Life Sciences Building, Corvallis, Oregon 97331-7305, United States.
Sahiti KuppaDepartment of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Edward A. Doisy Research Center, 1100 South Grand Blvd., St. Louis, Missouri 63104, United States.
Rachel FranklinDepartment of Biochemistry and Biophysics, Oregon State University, 2011 Agricultural & Life Sciences Building, Corvallis, Oregon 97331-7305, United States.
Joseph BeckmanDepartment of Biochemistry and Biophysics, Oregon State University, 2011 Agricultural & Life Sciences Building, Corvallis, Oregon 97331-7305, United States.ORCID 0000-0003-1855-4653
Edwin AntonyDepartment of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Edward A. Doisy Research Center, 1100 South Grand Blvd., St. Louis, Missouri 63104, United States.
Richard B CooleyDepartment of Biochemistry and Biophysics, Oregon State University, 2011 Agricultural & Life Sciences Building, Corvallis, Oregon 97331-7305, United States.ORCID 0000-0003-3928-2757
Ryan A MehlDepartment of Biochemistry and Biophysics, Oregon State University, 2011 Agricultural & Life Sciences Building, Corvallis, Oregon 97331-7305, United States.
Oregon State University · USSaint Louis University · US

Funding

Supplement Request for a FluorometerR01GM133967 · NIGMS · SAINT LOUIS UNIVERSITY · PI ANTONY, EDWIN · 2019 to 2023
$1.5M
Mechanisms of DNA hand-off during lesion repair in BER and NER supplementR01GM130746 · NIGMS · SAINT LOUIS UNIVERSITY · PI ANTONY, EDWIN · 2019 to 2022
$1.4M
Development of an improved core technology for efficient genetic code expansion in biomedical researchR01GM131168 · NIGMS · OREGON STATE UNIVERSITY · PI MEHL, RYAN A · 2019 to 2021
$1.1M
NIGMS NIH HHS R01 GM130746NIGMS NIH HHS R01 GM131168NIGMS NIH HHS R01 GM133967
6 · The paper itself

Abstract

The ability to site-specifically modify proteins at multiple sites

Indexed as

AlkenesAlkynesAminesAmino AcidsEscherichia coliFluorescent DyesProtein BindingProteinsAlkenesAlkynesAminesAmino AcidsFluorescent DyesProteins

Identifiers

PMID34590824
PMCPMC9377405
OpenAlexW3203820508

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.