Evidence map›Paper›PMID 34590817›Full record

ArticleACS infectious diseases2021

The Enzymatic Activity of Inosine 5'-Monophosphate Dehydrogenase May Not Be a Vulnerable Target for

Gyan Modi, Gary M Marqus, Mohana Rao Vippila, Deviprasad R Gollapalli, Youngchang Kim, Adhar C Manna, Shibin Chacko, Natalia Maltseva, Xingyou Wang, Ryan T Cullinane and 11 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. A journey into the regulatory secrets of theFrontiers in pharmacology · 2024
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 1 country.

Gyan ModiDepartment of Biology, Brandeis University, Waltham, Massachusetts 02453, United States.
Gary M MarqusGraduate Program in Chemistry, Brandeis University, Waltham Massachusetts 02453, United States.
Mohana Rao VippilaDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Health Building 2, 4849 Calhoun Rd., Houston, Texas 77204, United States.
Deviprasad R GollapalliDepartment of Biology, Brandeis University, Waltham, Massachusetts 02453, United States.
Youngchang KimCenter for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois 60667, United States.
Adhar C MannaDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755, United States.
Shibin ChackoDepartment of Biology, Brandeis University, Waltham, Massachusetts 02453, United States.
Natalia MaltsevaCenter for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois 60667, United States.
Xingyou WangGraduate Program in Chemistry, Brandeis University, Waltham Massachusetts 02453, United States.
Ryan T CullinaneDepartment of Biochemistry, Brandeis University, Massachusetts 02453, United States.
Yubo ZhangDepartment of Biochemistry, Brandeis University, Massachusetts 02453, United States.
Judy L M KotlerGraduate Program in Biochemistry and Biophysics, Brandeis University, Waltham, Massachusetts 02453, United States.
Petr KuzmicBioKin Ltd., Watertown, Massachusetts 02472, United States.
Minjia ZhangDepartment of Biology, Brandeis University, Waltham, Massachusetts 02453, United States.
Ann P LawsonDepartment of Biology, Brandeis University, Waltham, Massachusetts 02453, United States.
Andrzej JoachimiakCenter for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois 60667, United States.
Ambrose CheungDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755, United States.
Barry B SniderDepartment of Chemistry, Brandeis University, Waltham, Massachusetts 02453, United States.ORCID 0000-0002-2680-6104
David M RothsteinDavid Rothstein Consulting, LLC, Lexington, Massachusetts 02421, United States.
Gregory D CunyDepartment of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Health Building 2, 4849 Calhoun Rd., Houston, Texas 77204, United States.ORCID 0000-0002-3188-4748
Lizbeth HedstromDepartment of Biology, Brandeis University, Waltham, Massachusetts 02453, United States.ORCID 0000-0001-8432-3322
Brandeis University · USArgonne National Laboratory · USDartmouth College · USUniversity of Houston · USRuth M. Rothstein CORE Center · US

Funding

IMPDH inhibitors for the treatment of Cryptosporidium infectionsR01AI125362 · NIAID · UNIVERSITY OF HOUSTON · PI CUNY, GREGORY D · 2016 to 2020
$3.8M
Opportunities for multi-target drug discovery in tuberculosisR21AI138048 · NIAID · BRANDEIS UNIVERSITY · PI HEDSTROM, LIZBETH K. · 2019 to 2020
$445k
NIAID NIH HHS HHSN272201700060CNIAID NIH HHS R01 AI125362NIAID NIH HHS R21 AI138048
6 · The paper itself

Abstract

Many bacterial pathogens, including

Indexed as

Methicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsAnimalsIMP DehydrogenaseInosineMiceStaphylococcus aureusIMP DehydrogenaseInosineantibiotic spaceguaBguanine nucleotide biosynthesisIMPDHtarget vulnerabilityvirulence

Identifiers

PMID34590817
PMCPMC9575405
OpenAlexW3203544387

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.