Evidence map›Paper›PMID 34590692›Full record

ArticleClinical chemistry2021

CRISPR Cas9-Mediated Selective Isothermal Amplification for Sensitive Detection of Rare Mutant Alleles.

Junman Chen, Tian Qiu, Michael G Mauk, Yaguang Fan, Yong Jiang, Jianming Ying, Qinghua Zhou, Youlin Qiao, Haim H Bau, Jinzhao Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Expression and Functional Analysis of the Compact ThermophilicInternational journal of molecular sciences · 2023
    Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Junman ChenThe Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Tian QiuDepartment of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Michael G MaukDepartment of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA, USA.
Yaguang FanTianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China.
Yong JiangCenter for Global Health, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Jianming YingDepartment of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Qinghua ZhouSichuan Lung Cancer Institute, Sichuan Lung Cancer Center, West China Hospital, Chengdu, Sichuan University, China.
Youlin QiaoCenter for Global Health, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Haim H BauDepartment of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA, USA.
Jinzhao SongThe Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.

Funding

Smartphone-based detection of cancer mutant alleles in biological samplesR21TW011496 · FIC · UNIVERSITY OF PENNSYLVANIA · PI BAU, HAIM H, SONG, JINZHAO · 2019 to 2020
$406k
Smartphone-based mobile detection platform for lung cancer detection in ChinaK01TW011190 · FIC · UNIVERSITY OF PENNSYLVANIA · PI SONG, JINZHAO · 2019 to 2020
$225k
Beijing Hope Run Special Fund from the Cancer Foundation of China LC2019L04China Scholarship CouncilFIC NIH HHS K01 TW011190FIC NIH HHS R21 TW011496NIH HHS R21 CA228614-01A1University of Pennsylvania
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CRISPR-Cas SystemsNucleic Acid Amplification TechniquesAllelesHumansLimit of Detectionisothermal nucleic acids amplificationliquid biopsymutant allele enrichmentmutation detectionpoint-of-care testingprogrammable endonuclease

Identifiers

PMID34590692
PMCPMC8561782

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.