Evidence map›Paper›PMID 34590654›Full record

ArticleNanoscale2021

A numerical study on drug delivery

Mehdi Nikfar, Meghdad Razizadeh, Ratul Paul, Vladimir Muzykantov, Yaling Liu

Abstract read
In one paragraph

Article in Nanoscale, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Acoustofluidic Engineering of Functional Vessel-on-a-Chip.ACS biomaterials science & engineering · 2023
    Article
  7. Red blood cells: a potential delivery system.Journal of nanobiotechnology · 2023
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mehdi NikfarDepartment of Mechanical Engineering and Mechanics, Lehigh University, Bethlehem, Pennsylvania 18015, USA. yal310@lehigh.edu.ORCID http://orcid.org/0000-0003-4575-2727
Meghdad RazizadehDepartment of Mechanical Engineering and Mechanics, Lehigh University, Bethlehem, Pennsylvania 18015, USA. yal310@lehigh.edu.
Ratul PaulDepartment of Mechanical Engineering and Mechanics, Lehigh University, Bethlehem, Pennsylvania 18015, USA. yal310@lehigh.edu.
Vladimir MuzykantovDepartment of Systems Pharmacology and Translational Therapeutics and Center for Translational Targeted Therapeutics and Nanomedicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Yaling LiuDepartment of Mechanical Engineering and Mechanics, Lehigh University, Bethlehem, Pennsylvania 18015, USA. yal310@lehigh.edu.ORCID http://orcid.org/0000-0002-0385-6109

Funding

Vascular delivery of nanocarriers by erythrocyresR01HL143806 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MUZYKANTOV, VLADIMIR R · 2018 to 2021
$2.8M
BC-mediated delivery of thromboprophylaxisR01HL159256 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MUZYKANTOV, VLADIMIR R · 2021 to 2024
$2.6M
Supplement: Hemolysis Prediction Software DevelopmentR01HL131750 · NHLBI · LEHIGH UNIVERSITY · PI LIU, YALING · 2017 to 2021
$2.2M
NHLBI NIH HHS R01 HL131750NHLBI NIH HHS R01 HL143806NHLBI NIH HHS R01 HL159256
6 · The paper itself

Abstract

Red blood cell (RBC)-hitchhiking, in which different nanocarriers (NCs) shuttle on the erythrocyte membrane and disassociate from RBCs to the first organ downstream of the intravenous injection spot, has recently been introduced as a solution to enhance target site uptake. Several experimental studies have already approved that cellular hitchhiking onto the RBC membrane can improve the delivery of a wide range of NCs in mice, pigs, and

Indexed as

ErythrocytesPharmaceutical PreparationsAnimalsDrug Delivery SystemsErythrocyte MembraneMiceSwineTissue DistributionPharmaceutical Preparations

Identifiers

PMID34590654
PMCPMC10169096

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.