Evidence map›Paper›PMID 34590435›Full record

ArticleJournal of cachexia, sarcopenia and muscle2021

Is slowness a better discriminator of disability than frailty in older adults?

Dayane Capra de Oliveira, Roberta de Oliveira Máximo, Paula Camila Ramírez, Aline Fernanda de Souza, Mariane Marques Luiz, Maicon Luis Bicigo Delinocente, Marcos Hortes Nisihara Chagas, Andrew Steptoe, Cesar de Oliveira, Tiago da Silva Alexandre

Open access · goldAbstract read
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Does the incidence of frailty differ between men and women over time?Archives of gerontology and geriatrics · 2023
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Dayane Capra de OliveiraPostgraduate Program in Physical Therapy, Federal University of Sao Carlos, São Carlos, Brazil.ORCID 0000-0001-5825-4511
Roberta de Oliveira MáximoPostgraduate Program in Physical Therapy, Federal University of Sao Carlos, São Carlos, Brazil.ORCID 0000-0001-9757-9458
Paula Camila RamírezPostgraduate Program in Physical Therapy, Federal University of Sao Carlos, São Carlos, Brazil.ORCID 0000-0002-3534-794X
Aline Fernanda de SouzaPostgraduate Program in Physical Therapy, Federal University of Sao Carlos, São Carlos, Brazil.ORCID 0000-0001-9446-5201
Mariane Marques LuizPostgraduate Program in Physical Therapy, Federal University of Sao Carlos, São Carlos, Brazil.ORCID 0000-0001-5563-6354
Maicon Luis Bicigo DelinocentePostgraduate Program in Gerontology, Federal University of Sao Carlos, São Carlos, Brazil.ORCID 0000-0001-8066-5480
Marcos Hortes Nisihara ChagasPostgraduate Program in Gerontology, Federal University of Sao Carlos, São Carlos, Brazil.ORCID 0000-0003-3752-7984
Andrew SteptoeDepartment of Epidemiology and Public Health, University College of London (UCL), London, England.ORCID 0000-0001-7808-4943
Cesar de OliveiraDepartment of Epidemiology and Public Health, University College of London (UCL), London, England.ORCID 0000-0002-4099-4762
Tiago da Silva AlexandrePostgraduate Program in Physical Therapy, Federal University of Sao Carlos, São Carlos, Brazil.ORCID 0000-0003-3791-9793
Universidade Federal de São Carlos · BRUniversity College London · GBIndustrial University of Santander · CO

Funding

Project-001R01AG017644 · NIA · UNIVERSITY OF LONDON INST OF NEUROLOGY · PI Andrew Steptoe · 2000 to 2026
$56.2M
NIA NIH HHS R01 AG017644NIA NIH HHS R01AG017644
6 · The paper itself

Abstract

backgroundThe trajectory of incident disability that occurs simultaneously with changes in frailty status, as well as how much each frailty component contributes to this process in the different sexes, are unknown. The objective of this study is to analyse the trajectory of the incidence of disability on basic and instrumental activities of daily living (BADL and IADL) as a function of the frailty changes and their components by sex over time.

methodsLongitudinal analyses of 1522 and 1548 of the English Longitudinal Study of Ageing study participants without BADL and IADL disability, respectively, and without frailty at baseline. BADL and IADL were assessed using the Katz and Lawton Scales and frailty by phenotype at 4, 8, and 12 years of follow-up. Generalized mixed linear models were calculated for the incidence of BADL and IADL disability, as an outcome, using changes in the state of frailty and its components, as the exposure, by sex in models fully adjusted for sociodemographic, behavioural, biochemical, and clinical characteristics.

resultsThe mean age, at baseline, of the 1522 eligible individuals free of BADL and free of frailty was 68.1 ± 6.2 years (52.1% women) and of the 1548 individuals free IADL and free frailty was 68.1 ± 6.1 years (50.6% women). Women who became pre-frail had a higher risk of incidence of disability for BADL and IADL when compared with those who remained non-frail (P < 0.05). Men and women who became frail had a higher risk of incidence of disability regarding BADL and IADL when compared with those who remained non-frail (P < 0.05). Slowness was the only component capable of discriminating the incidence of disability regarding BADL and IADL when compared with those who remained without slowness (P < 0.05). Weakness and low physical activity level in men and exhaustion in women also discriminated the incidence of disability (P < 0.05).

conclusionsSlowness is the main warning sign of functional decline in older adults. As its evaluation is easy, fast, and accessible, screening for this frailty component should be prioritized in different clinical contexts so that rehabilitation strategies can be developed to avoid the onset of disability.

Indexed as

FrailtyPersons with DisabilitiesActivities of Daily LivingAgedFemaleFrail ElderlyHumansLongitudinal StudiesMaleDisabilityFrailtyOlder adultsSlownessTrajectories

Identifiers

PMID34590435
PMCPMC8718056
OpenAlexW3202006020

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.