ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2022
Pulmonary function is associated with cognitive decline and structural brain differences.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Exploring the link between body physiology and cognition: the role of the brain and aging.npj aging · 2026Article
- Magnetoencephalography in human neuroscience research: planning, piloting, implementation and quality assurance.Nature protocols · 2026Review
- Plasma albumin and other indicators as risk factors for delayed neurocognitive recovery in elderly patients undergoing orthopedic surgery.BMC surgery · 2026Article
- Independent component analysis of brain network alterations associated with cognitive impairment in coal workers' pneumoconiosis.BMC medical imaging · 2026Article
- Association Between Pulmonary Function, Respiratory Muscle Strength and Cognitive Function in Chinese Community-Dwelling Older Adults.Clinical interventions in aging · 2026Article
- Association of pulmonary function with the risk of incident Alzheimer's disease: a prospective cohort and Mendelian randomization study.Aging clinical and experimental research · 2025Article
- Lung function and the risk of Parkinson's disease: a population-based cohort study.Journal of neurology · 2025Article
- Pulmonary function and motoric cognitive risk syndrome in older adults.Scientific reports · 2025Article
- Association between self-reported multimorbidity and longitudinal brain Aβ deposition in Alzheimer's disease.Nature communications · 2025Article
- Influence of lung function on macro- and micro-structural brain changes in mid- and late-life.International journal of surgery (London, England) · 2025Article
- Altered cognition in patients following pulmonary embolism.Frontiers in medicine · 2025Article
- Lung-brain crosstalk: Behavioral disorders and neuroinflammation in septic survivor mice.Brain, behavior, & immunity - health · 2024Article
- Lung function in relation to brain aging and cognitive transitions in older adults: A population-based cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- COPD, PRISm and lung function reduction affect the brain cortical structure: a Mendelian randomization study.BMC pulmonary medicine · 2024Article
- Associations of Epigenetic Age Estimators With Cognitive Function Trajectories in the Women's Health Initiative Memory Study.Neurology · 2024Article
- Lung Function and Brain MRI Outcomes in the Atherosclerosis Risk in Communities Neurocognitive Study.Journal of Alzheimer's disease : JAD · 2024Article
- Association of peak expiratory flow with motoric cognitive risk syndrome among older adults.Frontiers in aging neuroscience · 2024Article
- Therapeutic role of gut microbiota in lung injury-related cognitive impairment.Frontiers in nutrition · 2024Review
- Pulmonary Function Trajectories Preceding Death Among Older Adults: A Long-Term Community-Based Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Lung function and cognitive ability in children: a UK birth cohort study.BMJ open respiratory research · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The association of poor pulmonary function (PF) with cognitive trajectories and structural brain differences remains unclear. Within the Rush Memory and Aging Project, 1377 dementia-free subjects were followed up to 21 years. PF was assessed with a composite score measured at baseline. Global and domain-specific cognitive function was assessed annually constructed from 19 cognitive tests. A subsample of 351 participants underwent brain magnetic resonance imaging to investigate the cross-sectional association between PF and structural brain volumes. We found that low PF was related to faster decline in global cognition, and domain-specific function including episodic memory, semantic memory, working memory, visuospatial ability, and perceptual speed. In addition, low PF was associated with smaller volumes of total brain, white matter and gray matter, and larger white matter hyperintensities volume. Our results suggest that low PF is associated with faster cognitive decline, and both neurodegeneration and vascular brain lesions may underlie the association.
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