Evidence map›Paper›PMID 34590417›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2022

Committee on High-quality Alzheimer's Disease Studies (CHADS) consensus report.

Greg A Jicha, Erin L Abner, Steven E Arnold, Maria C Carrillo, Hiroko H Dodge, Steven D Edland, Keith N Fargo, Howard H Feldman, Larry B Goldstein, James Hendrix and 6 more

Abstract readConsensus Statement
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Celebrating 40 years of the University of Kentucky Alzheimer's Disease Research Center.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  4. Article
  5. Review
  6. Decentralized clinical trials for medications to reduce the risk of dementia: Consensus report and guidance.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  7. Review
  8. Article
  9. Committee on High-quality Alzheimer's Disease Studies (CHADS) consensus report.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Greg A JichaDepartment of Neurology & the Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.
Erin L AbnerDepartment of Epidemiology & the Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.
Steven E ArnoldDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Maria C CarrilloAlzheimer's Association, Chicago, Illinois, USA.
Hiroko H DodgeDepartment of Neurology & Layton Aging and Alzheimer's Disease Center, Oregon Health & Science University, Portland, Oregon, USA.
Steven D EdlandDivision of Biostatistics, School of Public Health and Human Longevity Science, University of California, San Diego, San Diego, California, USA.
Keith N FargoAlzheimer's Association, Chicago, Illinois, USA (affiliation at time of publication is CMT Research Foundation, Atlanta, Georgia, USA).
Howard H FeldmanDepartment of Neuroscience, University of California, San Diego, California, USA.
Larry B GoldsteinDepartment of Neurology, University of Kentucky, Lexington, Kentucky, USA.
James HendrixAlzheimer's Association, Chicago, Illinois, USA (affiliation at time of publication is LuMind IDSC Foundation, Burlington, Massachusetts, USA).
Ruth PetersDepartment of Psychology, University of New South Wales, Sydney, New South Wales, Australia.
Julie M RobillardDivision of Neurology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Lon S SchneiderKeck School of Medicine, University of Southern California, Los Angeles, California, USA.
Jodi R TitinerAlzheimer's Association, Chicago, Illinois, USA.
Christopher J WeberAlzheimer's Association, Chicago, Illinois, USA.
Clinical Trial Advancement & Methodology Professional Interest Area of the International Society to Advance Alzheimer's Research and Treatment (ISTAART)

Funding

UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Mark W Bondi · 2019 to 2026
$34.9M
Research Education ComponentP30AG066518 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Zachary Beattie · 2020 to 2026
$28.6M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
University of Kentucky Alzheimer's Disease Research CenterP30AG072946 · NIA · UNIVERSITY OF KENTUCKY · PI LINDA J VAN ELDIK · 2021 to 2026
$23.5M
ARMADA: Advancing Reliable Measurement in Alzheimer's Disease and cognitive Aging - Tech CoreU2CAG057441 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GERSHON, RICHARD · 2017 to 2019
$10.8M
Michigan Alzheimer's Disease Core CenterP30AG053760 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALBIN, ROGER L · 2016 to 2020
$10.1M
Pilot CoreP30AG024978 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KAYE, JEFFREY A · 2004 to 2023
$9.0M
Resource CoreU2CAG054397 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KAYE, JEFFREY A · 2016 to 2019
$7.0M
Lewy Body Dementia BiomarkersU01NS100611 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FREY, KIRK A. · 2016 to 2022
$4.0M
White matter hyperintensity-associated astrocytopathy in Alzheimers disease and vascular cognitive impairment A targeted histopathologic study using postmortem 7T MRIR01AG056712 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI SILBERT, LISA C, WOLTJER, RANDALL L · 2018 to 2022
$3.8M
Community-based approach to Early Identification of transitions to Mild Cognitive Impairment (MCI) and Alzheimer’s Disease (AD) in African AmericansR01AG054484 · NIA · WAYNE STATE UNIVERSITY · PI KAVCIC, VOYKO · 2018 to 2022
$3.3M
Preclinical Development of Antisense Oligonucleotide Therapy for Spinocerebellar Ataxia Type 3U01NS106670 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCLOUGHLIN, HAYLEY SARAH, PAULSON, HENRY L · 2018 to 2021
$2.1M
NIA NIH HHS P30 AG024978NIA NIH HHS P30 AG053760NIA NIH HHS P30 AG062429NIA NIH HHS P30 AG066518NIA NIH HHS P30 AG066530NIA NIH HHS P30 AG072946NIA NIH HHS R01 AG054484NIA NIH HHS R01 AG056712NIA NIH HHS R21 AG062679NIA NIH HHS U2C AG054397NIA NIH HHS U2C AG057441NINDS NIH HHS U01 NS100611NINDS NIH HHS U01 NS106670
6 · The paper itself

Abstract

backgroundConsensus guidance for the development and identification of high-quality Alzheimer's disease clinical trials is needed for protocol development and conduct of clinical trials.

methodsAn ad hoc consensus committee was convened in conjunction with the Alzheimer's Association to develop consensus recommendations.

resultsConsensus was readily reached for the need to provide scientific justification, registration of trials, institutional review board oversight, conflict of interest disclosure, funding source disclosure, defined trial population, recruitment resources, definition of the intervention, specification of trial duration, appropriate payment for participant engagement, risk-benefit disclosure as part of the consent process, and the requirement to disseminate and/or publish trial results even if the study is negative.

conclusionsThis consensus guidance should prove useful for the protocol development and conduct of clinical trials, and may further provide a platform for the development of education materials that may help guide appropriate clinical trial participation decisions for potential trial participants and the general public.

Indexed as

Alzheimer DiseaseDisclosureEthics Committees, ResearchHumansResearch DesignAlzheimer's diseaseclinical trialconsensusDelphidementia

Identifiers

PMID34590417
PMCPMC8960469

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.