Evidence map›Paper›PMID 34590156›Full record

ArticleOncology reports2021

Curcumol inhibits the malignant progression of prostate cancer and regulates the PDK1/AKT/mTOR pathway by targeting miR‑9.

Wen Sheng, Wenjing Xu, Jin Ding, Ling Li, Xujun You, Yongrong Wu, Qinghu He

Open access · hybridAbstract read
In one paragraph

Article in Oncology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Anoikis: To Die or Not to Die?International journal of molecular sciences · 2026
    Review
  3. Chinese herbal medicines · 2025
    Review
  4. Curcumol ameliorates diabetic retinopathyWorld journal of diabetes · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Icaritin-curcumol activates CD8Journal of experimental & clinical cancer research : CR · 2024
    Article
  11. Article
  12. miRNAs as short non-coding RNAs in regulating doxorubicin resistance.Journal of cell communication and signaling · 2023
    Review
  13. [Curcumol reverses temozolomide resistance in glioma cells by regulating the UTX/MGMT axis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023
    Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Curcumol Inhibits the Development of Prostate Cancer by miR-125a/STAT3 Axis.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Wen Sheng *Andrology Laboratory, Hunan University of Chinese Medicine, Changsha, Hunan 410208, P.R. China.
Wenjing Xu *Dermatology Department, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410021, P.R. China.
Jin DingAndrology Clinic, Shenzhen Baoan Hospital of Traditional Chinese Medicine, Shenzhen, Guangdong 518133, P.R. China.
Ling LiMedical Basic Teaching Experiment Center, Hunan University of Chinese Medicine, Changsha, Hunan 410208, P.R. China.
Xujun YouAndrology Clinic, Shenzhen Baoan Hospital of Traditional Chinese Medicine, Shenzhen, Guangdong 518133, P.R. China.
Yongrong WuAndrology Laboratory, Hunan University of Chinese Medicine, Changsha, Hunan 410208, P.R. China.
Qinghu HeAndrology Laboratory, Hunan University of Chinese Medicine, Changsha, Hunan 410208, P.R. China.
Hunan University of Traditional Chinese Medicine · CNHunan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Curcumol has been reported to exert anti‑tumor activity, but its intrinsic molecular mechanism in prostate cancer remains to be elucidated. The present study aimed to analyze the effect of curcumol on prostate cancer and identify its possible internal regulatory pathway using

Indexed as

AnimalsCell Line, TumorCell ProliferationHumansMaleMiceMice, Inbred BALB CMicroRNAsPC-3 CellsProstatic NeoplasmsProto-Oncogene Proteins c-aktPyruvate Dehydrogenase Acetyl-Transferring KinaseSesquiterpenesTOR Serine-Threonine KinasesUp-RegulationcurcumolMicroRNAsMIRN92 microRNA, humanMTOR protein, humanPDK1 protein, humanProto-Oncogene Proteins c-aktPyruvate Dehydrogenase Acetyl-Transferring KinaseSesquiterpenesTOR Serine-Threonine KinasescurcumolmicroRNA‑9prostate cancerpyruvate dehydrogenase kinase 1/AKT/mTOR pathway

Identifiers

PMID34590156
PMCPMC8493056
OpenAlexW3202356134

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.