Evidence map›Paper›PMID 34590136›Full record

ArticleThe Journal of infectious diseases2021

Herpes Zoster Vaccines.

Ruth Harbecke, Jeffrey I Cohen, Michael N Oxman

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05898464 (Immunogenicity and Safety of Recombinant Zoster Vaccine in People Living With HIV), which is not on this map. Cited by 123 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed, 8 pooled it
17.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05898464 phase4completednot on this mapstarted 2023, after this paper: background citation

Immunogenicity and Safety of Recombinant Zoster Vaccine in People Living With HIV

TypeinterventionalSponsorSeoul National University HospitalRan2023 to 2026Enrolled71ConditionsVaccination, Infection, Vaccine Adverse ReactionArmsRecombinant zoster vaccination
3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 8 syntheses or guidelines pooled it, 181 citations in OpenAlex.

  1. Pooled it
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  6. Corticosteroids for preventing postherpetic neuralgia.The Cochrane database of systematic reviews · 2023
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Article
  10. Article
  11. Article
  12. Article
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  14. Perioperative shingles diagnosis does not influence prosthetic joint infection rates after shoulder arthroplasty.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026
    Article
  15. Review
  16. Vaccinations in patients with interstitial lung diseases: a narrative review.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  17. Review
  18. Article
  19. Article
  20. Article

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Ruth HarbeckeDepartment of Veterans Affairs (VA) San Diego Healthcare System, San Diego, California, USA.
Jeffrey I CohenLaboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Michael N OxmanDepartment of Veterans Affairs (VA) San Diego Healthcare System, San Diego, California, USA.
National Institute of Allergy and Infectious Diseases · USUniversity of California, San Diego · USVA San Diego Healthcare System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herpes zoster (HZ) affects approximately 1 in 3 persons in their lifetime, and the risk of HZ increases with increasing age. The most common, debilitating complication of HZ is the chronic neuropathic pain of postherpetic neuralgia (PHN). Two herpes zoster vaccines, a live-attenuated varicella-zoster virus (VZV) vaccine (zoster vaccine live [ZVL]; ZOSTAVAX [Merck]) and an adjuvanted VZV glycoprotein E (gE) subunit vaccine (recombinant zoster vaccine [RZV]; SHINGRIX [GlaxoSmithKline]) are licensed for the prevention of HZ and PHN in healthy older adults. The safety and efficacy of both vaccines has been demonstrated in clinical trials in immunocompetent adults and in selected immunocompromised persons and persons with immune-mediated diseases. Numerous real-world effectiveness studies have confirmed the safety and effectiveness of both ZVL and RZV. Recombinant zoster vaccine (RZV) is more effective for prevention of HZ than ZVL. Recombinant zoster vaccine is nonreplicating and is thus safe in immunocompromised persons. Additional zoster vaccines are in different stages of development. Wider distribution of safe and effective zoster vaccines will improve the health and well being of the rapidly growing population of older adults around the world.

Indexed as

Herpesvirus 3, HumanHerpes ZosterHerpes Zoster VaccineHumansVaccines, SubunitVaccines, SyntheticHerpes Zoster VaccineVaccines, SubunitVaccines, Syntheticherpes zosterlive attenuated Oka varicella-zoster vaccinerecombinant zoster vaccinezoster vaccine

Identifiers

PMID34590136
PMCPMC8482024
OpenAlexW2605201806

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.