Evidence map›Paper›PMID 34589994›Full record

ArticleJTO clinical and research reports2021

BRCA1 Expression and Outcome in Patients With

Niki Karachaliou, Oscar Arrieta, Ana Giménez-Capitán, Erika Aldeguer, Ana Drozdowskyj, Imane Chaib, Noemí Reguart, Rosario Garcia-Campelo, Jing-Hua Chen, Miguel Angel Molina-Vila and 2 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in JTO clinical and research reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07303218 (The HER Project), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07303218 active not recruitingnot on this mapstarted 2025, after this paper: background citation

The HER Project: Homologous Recombination Deficiency in EGFR-Mutated NSCLC, a Retrospective and Prospective Translational Single-center Study

TypeobservationalSponsorIRCCS San RaffaeleRan2025 to 2032Enrolled100ConditionsEGFR, Non Small Cell Lung Cancer, Homologous Recombination Deficiency, PARP InhibitorArmsNo Intervention: Observational Cohort
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. [DNA Damage Repair System and Antineoplastic Agents in Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Niki KarachaliouPangaea Oncology, Quirón-Dexeus University Hospital, Barcelona, Spain.
Oscar ArrietaThoracic Oncology Unit, Instituto Nacional de Cancerología, Mexico City, Mexico.
Ana Giménez-CapitánPangaea Oncology, Quirón-Dexeus University Hospital, Barcelona, Spain.
Erika AldeguerPangaea Oncology, Quirón-Dexeus University Hospital, Barcelona, Spain.
Ana DrozdowskyjMolecular and Cellular Oncology Laboratory, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Badalona, Spain.
Imane ChaibMolecular and Cellular Oncology Laboratory, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Badalona, Spain.
Noemí ReguartMedical Oncology Department, Hospital Clínic Barcelona, Barcelona, Spain.
Rosario Garcia-CampeloMedical Oncology Department, University Hospital A Coruña (XXIAC-SERGAS), A Coruña, Spain.
Jing-Hua ChenGuangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China.
Miguel Angel Molina-VilaPangaea Oncology, Quirón-Dexeus University Hospital, Barcelona, Spain.
Rafael RosellPangaea Oncology, Quirón-Dexeus University Hospital, Barcelona, Spain.
Spanish Lung Cancer Group (SLCG)
Hospital Universitario Dexeus · ESInstitut d'Investigació en Ciències de la Salut Germans Trias i Pujol · ESHospital Clínic de Barcelona · ESInstituto Nacional de Cancerología · MXInstituto Oncológico Dr. Rosell · ESServicio Gallego de Salud · ESTwelfth Guangzhou City People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDNA repair capacity, as exemplified by

methodsWe evaluated the impact of

resultsOverall, as what happened in the GOAL study, no statistically significant difference was observed in median progression-free survival (PFS) between the two treatment arms, for the 91 patients of the present study (

conclusionsHigh

Indexed as

EGFRGefitinibGOAL studyLung cancerOlaparib

Identifiers

PMID34589994
PMCPMC8474244
OpenAlexW3093628286

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.