Evidence map›Paper›PMID 34589894›Full record

ArticleBrain, behavior, & immunity - health2020

An enriched environment prevents cognitive impairment in an Alzheimer's disease model by enhancing the secretion of exosomal microRNA-146a from the choroid plexus.

Masako Nakano, Kenta Kubota, Shin Hashizume, Eiji Kobayashi, Takako S Chikenji, Yuki Saito, Mineko Fujimiya

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, & immunity - health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Neuroinflammation in Alzheimer disease.Nature reviews. Immunology · 2025
    Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. A state-of-the-art review on miRNA in prevention and treatment of AlzheimerZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2023
    Review
  17. Review
  18. Enriched environment as a nonpharmacological neuroprotective strategy.Experimental biology and medicine (Maywood, N.J.) · 2023
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Masako NakanoDepartment of Anatomy, Sapporo Medical University, School of Medicine, Sapporo, Hokkaido, Japan.
Kenta KubotaDepartment of Anatomy, Sapporo Medical University, School of Medicine, Sapporo, Hokkaido, Japan.
Shin HashizumeDepartment of Anatomy, Sapporo Medical University, School of Medicine, Sapporo, Hokkaido, Japan.
Eiji KobayashiDepartment of Anatomy, Sapporo Medical University, School of Medicine, Sapporo, Hokkaido, Japan.
Takako S ChikenjiDepartment of Anatomy, Sapporo Medical University, School of Medicine, Sapporo, Hokkaido, Japan.
Yuki SaitoDepartment of Anatomy, Sapporo Medical University, School of Medicine, Sapporo, Hokkaido, Japan.
Mineko FujimiyaDepartment of Anatomy, Sapporo Medical University, School of Medicine, Sapporo, Hokkaido, Japan.
Sapporo Medical University · JPHealth Sciences University of Hokkaido · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is characterized by the extensive deposition of amyloid-β plaques and neurofibrillary tangles. We previously found that preserved function of astrocytes is associated with cognitively normal subjects with AD pathology. Here we show that an enriched environment (EE) can prevent cognitive impairment in AD model mice by ameliorating astrocytic inflammation and increasing synaptic density in the subiculum area of the hippocampus. In AD model mice treated with an EE, increased levels of microRNA (miR)-146a and down-regulation of NF-κB were observed in the hippocampus. In addition, increased levels of interferon (IFN)-γ were seen in serum from mice exposed to an EE.

Indexed as

Alzheimer’s diseaseAstrocytesChoroid plexusEnriched environmentExosomal microRNA-146aInterferon-γ

Identifiers

PMID34589894
PMCPMC8474441
OpenAlexW3088749493

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.