ArticleBrain, behavior, & immunity - health2020
Maternal separation leads to regional hippocampal microglial activation and alters the behavior in the adolescence in a sex-specific manner.
Article in Brain, behavior, & immunity - health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Environmental enrichment as an intervention to prevent behavioral and neurobiological consequences of maternal separation in rodents: a scope review.Neurobiology of stress · 2026Article
- Inflammatory mechanisms contribute to long-term cognitive deficits induced by perinatal asphyxia via interleukin-1.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- The relationship between neurodevelopmental disorders (NDDs) and NLRP3 inflammasome.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- Microglial depletion prevents visual deficits and retinal ganglion cell loss induced by early life stress in adult animals.Scientific reports · 2025Article
- Understanding Role of Maternal Separation in Depression, Anxiety,and Pain Behaviour: A Mini Review of Preclinical Research With Focus on Neuroinflammatory Pathways.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2025Review
- Unraveling sex differences in maternal and paternal care impacts on social behaviors and neurobiological responses to early-life adversity.Frontiers in neuroendocrinology · 2025Review
- Neonatal maternal separation impairs cognitive function and synaptic plasticity in adult male CD-1 mice.IBRO neuroscience reports · 2024Article
- Enduring memory consequences of early-life stress / adversity: Structural, synaptic, molecular and epigenetic mechanisms.Neurobiology of stress · 2024Review
- Early Life Adversity, Microbiome, and Inflammatory Responses.Biomolecules · 2024Review
- Unraveling the Influence of Litter Size, Maternal Care, Exercise, and Aging on Neurobehavioral Plasticity and Dentate Gyrus Microglia Dynamics in Male Rats.Brain sciences · 2024Article
- Combined Effect of Maternal Separation and Early-Life Immune Activation on Brain and Behaviour of Rat Offspring.Biomolecules · 2024Article
- Maternal Substance Use and Early-Life Adversity: Inducing Drug Dependence in Offspring, Interactions, Mechanisms, and Treatments.Addiction & health · 2024Review
- Chronic Stress in Early Development and Effects on Traumatic Brain Injury Outcome.Advances in neurobiology · 2024Review
- Stress and Microglia: A Double-edged Relationship.Advances in neurobiology · 2024Review
- Impacts of age and environment on postnatal microglial activity: Consequences for cognitive function following early life adversity.PloS one · 2024Article
- Maternal separation differentially modulates early pathology by sex in 5xFAD Alzheimer's disease-transgenic mice.Brain, behavior, & immunity - health · 2023Article
- Stressed Microglia: Neuroendocrine-Neuroimmune Interactions in the Stress Response.Endocrinology · 2023Review
- Resveratrol ameliorates maternal separation-induced anxiety- and depression-like behaviors and reduces Sirt1-NF-kB signaling-mediated neuroinflammation.Frontiers in behavioral neuroscience · 2023Article
- Maternal separation modifies spontaneous synaptic activity in the infralimbic cortex of stress-resilient male rats.PloS one · 2023Article
- The impact of environmental factors during maternal separation on the behaviors of adolescent C57BL/6 mice.Frontiers in molecular neuroscience · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early life adversities during childhood (such as maltreatment, abuse, neglect, or parental deprivation) may increase the vulnerability to cognitive disturbances and emotional disorders in both, adolescence and adulthood. Maternal separation (MS) is a widely used model to study stress-related changes in brain and behavior in rodents. In this study, we investigated the effect of MS (postnatal day 2-14, 3 h/day) in both, female and male adolescent mice. Specifically, we evaluated (i) the spatial working memory, anxiety and depressive-like behavior, (ii) the hippocampal synaptic gene expression, and (iii) the hippocampal neuroinflammatory response. Our results show that MS significantly increased depressive-like behavior in adolescent female mice and altered the spatial memory in adolescent male mice. In addition, MS led to decreased expression of genes related to synaptic function (
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