Evidence map›Paper›PMID 34589862›Full record

ArticleBrain, behavior, & immunity - health2020

Impaired cognitive function in Crohn's disease: Relationship to disease activity.

Gerard Clarke, Paul J Kennedy, John A Groeger, Eamonn Mm Quigley, Fergus Shanahan, John F Cryan, Timothy G Dinan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, & immunity - health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Emotional Disturbances and Crohn's Disease.Clinical practice and epidemiology in mental health : CP & EMH · 2025
    Review
  6. Article
  7. Article
  8. Brain signatures of chronic gut inflammation.Frontiers in psychiatry · 2023
    Article
  9. Article
  10. Article
  11. Inflammatory bowel disease-associatedFrontiers in cellular and infection microbiology · 2022
    Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gerard ClarkeAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Paul J KennedyAPC Microbiome Ireland, University College Cork, Cork, Ireland.
John A GroegerSchool of Applied Psychology, University College Cork, Cork, Ireland.
Eamonn Mm QuigleyAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Fergus ShanahanAPC Microbiome Ireland, University College Cork, Cork, Ireland.
John F CryanAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Timothy G DinanAPC Microbiome Ireland, University College Cork, Cork, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

aimsImpaired attention and response inhibition have been reported in patients with Crohn's disease (CD) in clinical remission. Prospective studies are needed to determine whether this is a stable feature of CD and whether a similar impairment is evident in ulcerative colitis (UC). Thus, our aims were to examine whether patients with CD and UC exhibited a persistent impairment in attentional performance, and if this impairment was related to key biological indices of relevance to cognition.

methodsA prospective observational study was conducted on fifteen patients with CD and 7 with UC in clinical remission recruited from a specialty clinic and 30 healthy matched control participants. A neuropsychological assessment was carried out at baseline (visit 1) and at a 6 month follow-up (visit 2). Plasma proinflammatory cytokines, the plasma kynurenine:tryptophan (Kyn:Trp) ratio and the salivary cortisol awakening response (CAR) were also determined at each visit.

resultsAcross visits, patients with CD exhibited impaired attentional performance (

conclusionsImpaired cognitive function is a stable feature of patients with CD. These data suggest that even where remission has been achieved, the functional impact of an organic gastrointestinal disorder on cognition is still evident. However, it is unclear at present if physiological changes due to disease activity play a role in cognitive impairment in CD.

Indexed as

ACC, anterior cingulate cortexBMI, body mass indexCANTAB®, Cambridge Neuropsychological Test Automated BatteryCAR, cortisol awakening responseCD, Crohn’s diseaseCognitionCrohn’s diseaseEM, Expectation-maximizationGut-brain axisHBI, Harvey Bradshaw IndexHSD, Honestly Significant DifferenceIBD, Inflammatory bowel diseaseIED, Intra-Extradimensional Set ShiftImmune systemInflammatory bowel diseaseMCAR, missing completely at randomMRT, mean response timePAL, Paired Associates LearningPFC, prefrontal cortexSCCAI, Short Clinical Colitis Activity IndexSWM, Spatial Working MemoryTryptophanUC, ulcerative colitis

Identifiers

PMID34589862
PMCPMC8474502

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.