Evidence map›Paper›PMID 34589854›Full record

ArticleBrain, behavior, & immunity - health2020

Systemic treatment with human amnion epithelial cells after experimental traumatic brain injury.

Hyun Ah Kim, Bridgette D Semple, Larissa K Dill, Louise Pham, Sebastian Dworkin, Shenpeng R Zhang, Rebecca Lim, Christopher G Sobey, Stuart J McDonald

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, & immunity - health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Hyun Ah KimDepartment of Physiology, Anatomy and Microbiology, La Trobe University, Bundoora, VIC, Australia.
Bridgette D SempleDepartment of Neuroscience, Monash University, Melbourne, VIC, Australia.
Larissa K DillDepartment of Neuroscience, Monash University, Melbourne, VIC, Australia.
Louise PhamDepartment of Physiology, Anatomy and Microbiology, La Trobe University, Bundoora, VIC, Australia.
Sebastian DworkinDepartment of Physiology, Anatomy and Microbiology, La Trobe University, Bundoora, VIC, Australia.
Shenpeng R ZhangDepartment of Physiology, Anatomy and Microbiology, La Trobe University, Bundoora, VIC, Australia.
Rebecca LimThe Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia.
Christopher G SobeyDepartment of Physiology, Anatomy and Microbiology, La Trobe University, Bundoora, VIC, Australia.
Stuart J McDonaldDepartment of Physiology, Anatomy and Microbiology, La Trobe University, Bundoora, VIC, Australia.
La Trobe University · AUAlfred Health · AUAustralian Regenerative Medicine Institute · AUMonash University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic administration of human amnion epithelial cells (hAECs) was recently shown to reduce neuropathology and improve functional recovery following ischemic stroke in both mice and marmosets. Given the significant neuropathological overlap between ischemic stroke and traumatic brain injury (TBI), we hypothesized that a similar hAEC treatment regime would also improve TBI outcomes. Male mice (12 weeks old, n ​= ​40) were given a sham injury or moderate severity TBI by controlled cortical impact. At 60 ​min post-injury, mice were given a single tail vein injection of either saline (vehicle) or 1 ​× ​10

Indexed as

BehaviorCell therapyControlled cortical impactFlow cytometryImmune cellsImmunologyMotor dysfunctionPlacentaSpleenStem cells

Identifiers

PMID34589854
PMCPMC8474600
OpenAlexW3016603231

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.