ArticleBrain, behavior, & immunity - health2021
Transdiagnostic biomarker approaches to mental health disorders: Consideration of symptom complexity, comorbidity and context.
Article in Brain, behavior, & immunity - health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Commonalities in frailty and psychopathology predict chronotype across severe mental disorders from a comorbidity perspective.Psychological medicine · 2026Article
- Subtypes of adolescent major depressive disorder characterized by divergent information dynamics in sensory-association cortices.Nature communications · 2026Article
- The kynurenine pathway in depression and schizophrenia: convergent signals, divergent states, and clinical signatures.EXCLI journal · 2026Review
- Electroencephalogram Gamma Band Power Correlates with Anhedonia in a Community Sample.Journal of personalized medicine · 2025Article
- A mega-analysis of low frequency resting-state measures in mood and psychosis-spectrum disorders.medRxiv : the preprint server for health sciences · 2025Article
- From Biomarkers to Behavior: Mapping the Neuroimmune Web of Pain, Mood, and Memory.Biomedicines · 2025Article
- Multilevel and multimodal biobehavioral methods in the study of stress, trauma, and resilience: a systems approach.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Article
- Aberrant functional connectivity of the dorsolateral prefrontal cortex-nucleus accumbens during naturalistic stimulation in adolescent major depressive disorder.Frontiers in psychiatry · 2025Article
- Editorial: Neuroimaging in psychiatry 2023: mood disorders.Frontiers in psychiatry · 2025Article
- Acceptability, User Satisfaction, and Feasibility of an App-Based Support Service During the COVID-19 Pandemic in a Psychiatric Outpatient Setting: Prospective Longitudinal Observational Study.JMIR formative research · 2024Observational
- Biomarker-Guided Tailored Therapy in Major Depression.Advances in experimental medicine and biology · 2024Review
- Does the current state of biomarker discovery in autism reflect the limits of reductionism in precision medicine? Suggestions for an integrative approach that considers dynamic mechanisms between brain, body, and the social environment.Frontiers in psychiatry · 2023Article
- High depression symptomatology and mental pain characterize suicidal psychiatric patients.European psychiatry : the journal of the Association of European Psychiatrists · 2022Article
- Association of Symptoms of Posttraumatic Stress Disorder and GrimAge, an Epigenetic Marker of Mortality Risk, in US Military Veterans.The Journal of clinical psychiatry · 2022Article
- Developing symptom clusters: linking inflammatory biomarkers to depressive symptom profiles.Translational psychiatry · 2022Article
- Narcissistic Personality and Its Relationship with Post-Traumatic Symptoms and Emotional Factors: Results of a Mediational Analysis Aimed at Personalizing Mental Health Treatment.Behavioral sciences (Basel, Switzerland) · 2022Article
- Editorial commentary on the special issue emerging psychoneuroimmunology research: Future leaders in focus.Brain, behavior, & immunity - health · 2022Article
- Comorbid depression and anxiety: Integration of insights from attachment theory and cognitive neuroscience, and their implications for research and treatment.Frontiers in behavioral neuroscience · 2022Article
- A Novel Adaptive Affective Cognition Analysis Model for College Students Using a Deep Convolution Neural Network and Deep Features.Computational intelligence and neuroscience · 2022Article
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
Depression is a multifaceted disorder characterized by heterogeneous symptom profiles and high rates of comorbidity with other commonly occurring mental illnesses. Considering the burden of mental health disorders and the lack of efficacy of available treatments, there is a need for biomarkers to predict tailored or personalized treatments. However, identifying reliable biomarkers for complex mental illnesses, such as depression, anxiety and PTSD, has been challenging, likely owing to the heterogeneity, comorbidity and differences in experiences and histories of individuals. For these reasons, taking a transdiagnostic approach, which identifies biomarkers that map onto shared symptoms/constructs across disorders could be most effective for informing personalized or precision medicine approaches in psychiatry. Transdiagnostic features of anxiety, depression and anhedonia have been examined in relation to brain activity and connectivity patterns. Neuroendocrine and inflammatory markers, which are altered in depression and other comorbid illness, such as post-traumatic stress disorder (PTSD), might be useful in differentiating transdiagnostic symptom profiles as well as treatment responses. Ultimately, biomarker research that looks beyond diagnostic categories and embraces the complexity of individuals' lives and experiences might be more effective in moving towards precision medicine in psychiatry.
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