Evidence map›Paper›PMID 34589766›Full record

ArticleBrain, behavior, & immunity - health2021

Sex differences in a murine model of Cerebral Amyloid Angiopathy.

Michael E Maniskas, Alexis F Mack, Diego Morales-Scheihing, Carson Finger, Liang Zhu, Robia Paulter, Akihiko Urayama, Louise D McCullough, Bharti Manwani

Open access · goldAbstract read
In one paragraph

Article in Brain, behavior, & immunity - health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Cerebral proteome adaptations to amyloid angiopathy are prevented by carbonic anhydrase inhibitors.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  7. Review
  8. Cerebral amyloid angiopathy: a narrative review.Frontiers in aging neuroscience · 2025
    Review
  9. Article
  10. Review
  11. Article
  12. Sex and interferon gamma signaling regulate microglia migration in the adult mouse cortex in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Michael E ManiskasDepartment of Neurology, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Alexis F MackDepartment of Neurology, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Diego Morales-ScheihingDepartment of Neurology, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Carson FingerDepartment of Neurology, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Liang ZhuDepartment of Neurology, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Robia PaulterDepartment of Molecular Physiology, Baylor College of Medicine, Houston, TX, 77030, USA.
Akihiko UrayamaDepartment of Neurology, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Louise D McCulloughDepartment of Neurology, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Bharti ManwaniDepartment of Neurology, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
The University of Texas Health Science Center at Houston · USBaylor College of Medicine · US

Funding

Dynamic Non-Neuronal Interactions between the Gut Microbiota and the Brain in Aging and in Cerebral Amyloid AngiopathyRF1AG058463 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BRYAN, ROBERT M, MCCULLOUGH, LOUISE D. · 2017 to 2017
$3.7M
Sexual Dimorphism in Cerebral Amyloid Angiopathy and Vascular Dementia: Investigating the Role of Fibrinolytic SystemR21AG070860 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MANWANI, BHARTI · 2021 to 2022
$429k
NIA NIH HHS R21 AG070860NIA NIH HHS RF1 AG058463
6 · The paper itself

Abstract

Cerebral amyloid angiopathy (CAA) is one of the common causes of lobar intracerebral hemorrhage and vascular cognitive impairment (VCI) in the aging population. Increased amyloid plaque deposition within cerebral blood vessels, specifically the smooth muscle layer, is linked to increased cerebral microbleeds (CMBs) and impaired cognition in CAA. Studies in Alzheimer's disease (AD) have shown that amyloid plaque pathology is more prevalent in the brains of elderly women (2/3rd of the dementia population) compared with men, however, there is a paucity of studies on sex differences in CAA

Indexed as

Cerebral amyloid angiopathyCerebral microbleedsCognitionMRI

Identifiers

PMID34589766
PMCPMC8474688
OpenAlexW3155347260

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.