Evidence map›Paper›PMID 34589753›Full record

ArticleBrain, behavior, & immunity - health2021

Exercise-induced modulation of monocytes in breast cancer survivors.

Nasim Khosravi, Erik D Hanson, Vahid Farajivafa, William S Evans, Jordan T Lee, Eli Danson, Chad W Wagoner, Elizabeth P Harrell, Stephanie A Sullivan, Kirsten A Nyrop and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, & immunity - health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Nasim KhosraviDepartment of Exercise & Sport Science, Exercise Oncology Research Laboratory, University of North Carolina, Chapel Hill, NC, USA.
Erik D HansonDepartment of Exercise & Sport Science, Exercise Oncology Research Laboratory, University of North Carolina, Chapel Hill, NC, USA.
Vahid FarajivafaDepartment of Exercise & Sport Science, Exercise Oncology Research Laboratory, University of North Carolina, Chapel Hill, NC, USA.
William S EvansDepartment of Exercise & Sport Science, Exercise Oncology Research Laboratory, University of North Carolina, Chapel Hill, NC, USA.
Jordan T LeeDepartment of Exercise & Sport Science, Exercise Oncology Research Laboratory, University of North Carolina, Chapel Hill, NC, USA.
Eli DansonDepartment of Exercise & Sport Science, Exercise Oncology Research Laboratory, University of North Carolina, Chapel Hill, NC, USA.
Chad W WagonerDepartment of Exercise & Sport Science, Exercise Oncology Research Laboratory, University of North Carolina, Chapel Hill, NC, USA.
Elizabeth P HarrellDepartment of Exercise & Sport Science, Exercise Oncology Research Laboratory, University of North Carolina, Chapel Hill, NC, USA.
Stephanie A SullivanDepartment of Exercise & Sport Science, Exercise Oncology Research Laboratory, University of North Carolina, Chapel Hill, NC, USA.
Kirsten A NyropLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
Hyman B MussLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
David B BartlettDepartment of Medicine, Duke University, Durham, NC, USA.
Brian C JensenDivision of Cardiology, University of North Carolina, Chapel Hill, NC, USA.
Shahpar HaghighatBreast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.
Mahdieh Molanouri ShamsiPhysical Education & Sport Sciences Department, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran.
Claudio L BattagliniDepartment of Exercise & Sport Science, Exercise Oncology Research Laboratory, University of North Carolina, Chapel Hill, NC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExercise training reduces inflammation in breast cancer survivors; however, the mechanism is not fully understood.

objectivesThe effects of acute and chronic exercise on monocyte toll-like receptor (TLR2 and 4) expression and intracellular cytokine production were examined in sedentary breast cancer survivors.

methodsEleven women with stage I, II, or III breast cancer within one year of treatment completion performed an acute, intermittent aerobic exercise trial. Blood samples were obtained before, immediately, and 1 h after a 45-min acute exercise trial that was performed before and after 16 weeks of combined aerobic and resistance. LPS-stimulated intracellular IL-1ß, TNF, and IL-6 production, and TLR2 and TLR4 expression were evaluated in CD14

resultsExercise training decreased IL-1ß

conclusionsExercise training reduced monocyte intracellular pro-inflammatory cytokine production, especially IL-1ß, although these markers did not change acutely. While acute exercise downregulated the expression of TLR2 and TLR4 on monocytes, this was not sustained over the course of training. These results suggest that the anti-inflammatory effect of combined aerobic and resistance exercise training in breast cancer survivors may be, in part, due to reducing resting monocyte pro-inflammatory cytokine production.

Indexed as

Breast cancerCytokinesExerciseInflammationMonocyteToll like receptor

Identifiers

PMID34589753
PMCPMC8474256

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.