Evidence map›Paper›PMID 34589741›Full record

ArticleBrain, behavior, & immunity - health2021

Inflammation is associated with future depressive symptoms among older adults.

Erin Bondy, Sara A Norton, Michaela Voss, Rebecca B Marks, Michael J Boudreaux, Michael T Treadway, Thomas F Oltmanns, Ryan Bogdan

Open access · goldAbstract read
In one paragraph

Article in Brain, behavior, & immunity - health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 33 citations in OpenAlex.

  1. Trial
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  4. Review
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  8. Inflammation is associated with pain and fatigue in older adults.Brain, behavior, & immunity - health · 2024
    Article
  9. Article
  10. Neuroinflammation in the Amygdala Is Associated With Recent Depressive Symptoms.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023
    Article
  11. Exploring the multiverse: the impact of researchers' analytic decisions on relationships between depression and inflammatory markers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  12. Review
  13. Article
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Erin BondyDepartment of Psychological and Brain Sciences, Washington University in St. Louis, USA.
Sara A NortonDepartment of Psychological and Brain Sciences, Washington University in St. Louis, USA.
Michaela VossDepartment of Psychological and Brain Sciences, Washington University in St. Louis, USA.
Rebecca B MarksDepartment of Psychological and Brain Sciences, Washington University in St. Louis, USA.
Michael J BoudreauxDepartment of Psychological and Brain Sciences, Washington University in St. Louis, USA.
Michael T TreadwayDepartment of Psychology, Emory University, USA.
Thomas F OltmannsDepartment of Psychological and Brain Sciences, Washington University in St. Louis, USA.
Ryan BogdanDepartment of Psychological and Brain Sciences, Washington University in St. Louis, USA.
Washington University in St. Louis · USEmory University · US

Funding

BIOMEDICAL RESEARCH TRAINING IN DRUG ABUSET32DA007261 · NIDA · WASHINGTON UNIVERSITY · PI ARPANA AGRAWAL, Jose A Moron-Concepcion · 1991 to 2026
$8.8M
Inflammation and Reward-related Behavioral and Neural PhenotypesF31MH123105 · NIMH · WASHINGTON UNIVERSITY · PI BONDY, ERIN · 2020 to 2022
$92k
NIDA NIH HHS T32 DA007261NIMH NIH HHS F31 MH123105
6 · The paper itself

Abstract

Inflammation has been reliably associated with depression. However, the directionality of this association is poorly understood, with evidence that elevated inflammation may promote and precede the development of depression, as well as arise following its expression. Using data from older adults (

Identifiers

PMID34589741
PMCPMC8474183
OpenAlexW3129658630

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.