Evidence map›Paper›PMID 34589719›Full record

ArticleBrain, behavior, & immunity - health2021

Improvements in sleep indices during exam stress due to consumption of a

Gerard M Moloney, Caitriona M Long-Smith, Amy Murphy, Danielle Dorland, Sara Firuzeh Hojabri, Loreto Olavarría Ramirez, David Campos Marin, Thomaz F S Bastiaanssen, Anne-Marie Cusack, Kirsten Berding and 6 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, & immunity - health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07752342 (Exploring Wellbeing Outcomes in Adolescents Using Bifidobacterium Longum, 1714™), which is not on this map. Cited by 44 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 6 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07752342 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Exploring Wellbeing Outcomes in Adolescents Using Bifidobacterium Longum, 1714™: a Prospective Open-Label Real-World Study

TypeinterventionalSponsorNovonesisRan2026 to 2027Enrolled150ConditionsHealthy Young AdultsArmsBifidobacterium longum, 1714™
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 6 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
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  11. Nutrients · 2023
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  19. Dual-Strain Psychobiotics Combining LiveFoods (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Gerard M MoloneyAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Caitriona M Long-SmithAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Amy MurphyAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Danielle DorlandAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Sara Firuzeh HojabriAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Loreto Olavarría RamirezAPC Microbiome Ireland, University College Cork, Cork, Ireland.
David Campos MarinAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Thomaz F S BastiaanssenAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Anne-Marie CusackAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Kirsten BerdingAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Fiona FouhyAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Andrew P AllenAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Catherine StantonAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Gerard ClarkeAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Timothy G DinanAPC Microbiome Ireland, University College Cork, Cork, Ireland.
John F CryanAPC Microbiome Ireland, University College Cork, Cork, Ireland.
University College Cork · IETeagasc - The Irish Agriculture and Food Development Authority · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Targeting the gut microbiome as an effective therapeutic strategy for psychological disorders has shown promise in recent years. Variation in the composition of the microbiota and restoration of a stable microbiome using targeted interventions (psychobiotics) including Bifidobacteria have shown promise in pre-clinical studies, but more human data is required on the potential health benefits of these live microorganisms

Indexed as

Bif, BifidobacteriumCANTAB, Cambridge Neuropsychological Test Automated BatteryHPA, hypothalamic-pituitary-adrenal axisPlacebo-controlledPsychobioticsSleepStress

Identifiers

PMID34589719
PMCPMC8474585
OpenAlexW3105686112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.