ArticlePediatric investigation2021
Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China: A multicenter retrospective study.
Article in Pediatric investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 21 citations in OpenAlex.
- Acyclovir and ganciclovir exposure and short-term outcomes in hospitalized children with EBV-associated mononucleosis-like illness: a retrospective cohort study using inverse probability of treatment weighting.Translational pediatrics · 2026Article
- Age-Dependent Clinical Patterns of Primary Epstein-Barr Virus Infection in Children: Insights for Diagnostic Accuracy.Pathogens (Basel, Switzerland) · 2026Article
- The Difference in Clinical Features and Hepatic Injury Characteristics Between Children and Adults With Infectious Mononucleosis.JGH open : an open access journal of gastroenterology and hepatology · 2026Article
- A routine blood parameter-based nomogram to predict prolonged fever in children with primary EBV infection.Frontiers in pediatrics · 2026Article
- Infectious mononucleosis complicated with Kawasaki disease: Two case reports and literature review.Pediatric investigation · 2025Article
- Effect of interferon combined with ganciclovir on immune status in children with infectious mononucleosis.Pakistan journal of medical sciences · 2025Article
- Clinical Features and Laboratory Findings of Hospitalized Children with Infectious Mononucleosis Caused by Epstein-Barr Virus from Croatia.Pathogens (Basel, Switzerland) · 2025Article
- Analysis of the Network Pharmacology Mechanism and Clinical Efficacy of Qingre Jiedu Decoction (QJD) in the Treatment of Infectious Mononucleosis (IM) in Children.Drug design, development and therapy · 2025Article
- Dysfunction of γδ T cells in pediatric chronic active Epstein-Barr virus infection.Italian journal of pediatrics · 2024Article
- Therapeutic effect of intravenous acyclovir in children with infectious mononucleosis and immune function.American journal of translational research · 2023Article
- Treatment Options for Epstein-Barr Virus-Related Disorders of the Central Nervous System.Infection and drug resistance · 2023Review
- Gamma globulin combined with acyclovir for children with infectious mononucleosis and their effect on immune function.American journal of translational research · 2023Article
- Epidemiological characteristics and disease burden of infectious mononucleosis in hospitalized children in China: A nationwide retrospective study.Virologica Sinica · 2022Article
- Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China: A multicenter retrospective study.Pediatric investigation · 2021Article
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22 authors at 6 institutions in 1 country.
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Abstract
importanceThe clinical characteristics of infectious mononucleosis (IM) in Chinese children have not been evaluated in multicenter studies, and the effectiveness of antiviral treatment are controversial.
objectiveTo investigate the clinical characteristics of Chinese children with IM and current status of antiviral therapy for affected patients.
methodsHospitalized patients with IM were enrolled between 2018 and 2020 in five children's hospitals in China. The clinical characteristics were compared among four age groups: <3 years, 3-<6 years, 6-<10 years, and ≥10 years. The clinical characteristics of IM and effectiveness of antiviral therapy were compared among patients receiving acyclovir (ACV), ganciclovir (GCV), and no antiviral therapy (i.e., non-antiviral group).
resultsIn total, 499 patients were analyzed; most patients were 3-<6 years of age. The most common symptoms and signs included fever (100%), lymphadenopathy (98.6%), pharyngitis (86.4%), eyelid edema (76.8%), and snoring (72.9%). There were significant differences in rash, hepatomegaly, and liver dysfunction among the four age groups. Patients aged < 3 years had a lower incidence of liver dysfunction and a higher incidence of rash. Among the 499 patients, 50.1% were treated with GCV, 26.3% were treated with ACV, and 23.6% received no antiviral therapy. Compared with the non-antiviral group, patients in the ACV and GCV groups had longer durations of fever (
interpretationThe incidence of IM in Chinese children peaked at 3-<6 years of age. Clinical features of IM varied according to age. Patients receiving antiviral therapy exhibited more serious clinical manifestations than did patients without antiviral therapy. The effectiveness of antiviral therapy for IM requires further analysis.
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