Evidence map›Paper›PMID 34589656›Full record

ArticleExploratory research and hypothesis in medicine2021

Role of Yes-associated Protein-1 in Gastrointestinal Cancers and Hepatocellular Carcinoma.

Xia Qian, Wei Zhang, Hua Yang, Lanjing Zhang, Ningling Kang, Jinping Lai

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Exploratory research and hypothesis in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Xia Qian *Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, Gainesville, FL, USA.
Wei Zhang *Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, Gainesville, FL, USA.
Hua YangDepartment of Ophthalmology, Emory Eye Center, Emory University, Atlanta, GA, USA.
Lanjing ZhangDepartment of Pathology, Princeton Medical center, Rutgers University, Plainsboro, NJ, USA.
Ningling KangTumor Microenvironment and Metastasis, Hormel Institute, University of Minnesota, Austin, MN, USA.
Jinping LaiDepartment of Pathology and Laboratory Medicine, Kaiser Permanente Sacramento Medical Center, Sacramento, CA, USA.ORCID 0000-0002-4234-5096
University of Florida · USEmory Eye Center · USKaiser Permanente Sacramento Medical Center · US

Funding

HEPATIC STELLATE CELL REGULATION OF METASTATIC GROWTH IN THE LIVERR01CA160069 · NCI · UNIVERSITY OF MINNESOTA · PI NINGLING KANG · 2011 to 2026
$5.2M
Chemoprevention of colon cancer by targeting the Wnt/beta-catenin pathwayR01CA187027 · NCI · UNIVERSITY OF MINNESOTA · PI KANG, NINGLING, ROH, EUNMIRI · 2015 to 2019
$1.7M
NCI NIH HHS R01 CA160069NCI NIH HHS R01 CA187027
6 · The paper itself

Abstract

Yes-associated protein-1 (YAP1) is a potent transcriptional co-activator and functions as an important downstream effector of the Hippo signaling pathway, which is key to regulating cell proliferation, apoptosis, and organ growth. YAP1 has been implicated as an oncogene for various human cancers including gastrointestinal cancers and hepatocellular carcinoma (HCC). YAP1 promotes tumorigenesis and cancer progression by multiple mechanisms, such as by promoting malignant phenotypes, expanding cancer stem cells, and inducing epithelial-mesenchymal transition. YAP1 overexpression or its activated forms are associated with advanced pathological grades and poor prognosis of cancer, and therefore targeting YAP1 may open a fertile avenue for cancer therapy. In this review, we summarize the recent evidence regarding the role of YAP1 in the carcinogenesis of gastrointestinal cancers and HCC.

Indexed as

Cancer therapyCarcinogenesisGastrointestinal cancersHepatocellular carcinomasYAP1

Identifiers

PMID34589656
PMCPMC8478289
OpenAlexW3170656874

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.