Evidence map›Paper›PMID 34589642›Full record

ArticlePain reports

Psychophysiologic symptom relief therapy for chronic back pain: a pilot randomized controlled trial.

Michael W Donnino, Garrett S Thompson, Shivani Mehta, Myrella Paschali, Patricia Howard, Sofie B Antonsen, Lakshman Balaji, Suzanne M Bertisch, Robert Edwards, Long H Ngo and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pain reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. A Systematic Review of the Adherence to Home-Practice Meditation Exercises in Patients with Chronic Pain.International journal of environmental research and public health · 2023
    Pooled it
  2. 'I Want Everyone to Have It, and Everyone to Be on It': A Feasibility Study of the Transforming Long Covid Intervention.Health expectations : an international journal of public participation in health care and health policy · 2026
    Article
  3. Review
  4. 'The Second Arrow': A Collaborative Autoethnographic Exploration of What Can Be Learned From One Long COVID Journey.Health expectations : an international journal of public participation in health care and health policy · 2025
    Article
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  11. Psychophysiologic Symptom Relief Therapy (PSRT) for Post-acute Sequelae of COVID-19.Mayo Clinic proceedings. Innovations, quality & outcomes · 2023
    Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Michael W DonninoDivision of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID 0000-0002-8541-8099
Garrett S ThompsonCenter for Resuscitation Science, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID 0000-0002-2676-6843
Shivani MehtaCenter for Resuscitation Science, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Myrella PaschaliDepartment of Anesthesiology, Harvard Medical School, Brigham & Women's Hospital, Chestnut Hill, MA, USA.ORCID 0000-0002-2438-7268
Patricia HowardCenter for Resuscitation Science, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID 0000-0001-6049-7707
Sofie B AntonsenCentre for Child and Adolescent Psychiatry, Aarhus University Hospital, Aarhus, Denmark.
Lakshman BalajiCenter for Resuscitation Science, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID 0000-0001-7189-4775
Suzanne M BertischDivision of General Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID 0000-0002-4627-8871
Robert EdwardsDepartment of Anesthesiology, Harvard Medical School, Brigham & Women's Hospital, Chestnut Hill, MA, USA.
Long H NgoDivision of General Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Anne V GrossestreuerCenter for Resuscitation Science, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Beth Israel Deaconess Medical Center · USBrigham and Women's Hospital · USAarhus University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChronic back pain is the leading cause of disability in the United States. Based on the hypothesis that nonspecific back pain may be rooted in a psychophysiologic etiology, we propose a new approach to chronic back pain.

objectivesA pilot study was conducted to assess whether psychophysiologic symptom relief therapy (PSRT) can reduce disability and back pain bothersomeness for patients with chronic back pain.

methodsThis was a three-armed, randomized trial for adults with nonspecific chronic back pain that compared PSRT with usual care and an active comparator (mindfulness-based stress reduction [MBSR]). Psychophysiologic symptom relief therapy-randomized participants received a 12-week (36 hours) course based on the psychophysiological model of pain. All groups were administered validated questionnaires at baseline and at 4, 8, 13, and 26 weeks. The primary outcome was the reduction in pain disability measured by the Roland-Morris Disability Questionnaire.

resultsThe mean Roland-Morris Disability Questionnaire score for the PSRT group (n = 11) decreased from 9.5 (±4.3 SDs) to 3.3 (±5.1) after 26 weeks which was statistically significant compared with both MBSR (n = 12) (

conclusionPsychophysiologic symptom relief therapy is a feasible and potentially highly beneficial treatment for patients with nonspecific back pain.

Indexed as

Back painChronic painMind–body therapiesPsychosomatic medicineRandomized control trial

Identifiers

PMID34589642
PMCPMC8476063
OpenAlexW3202735110

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.