Evidence map›Paper›PMID 34589641›Full record

ArticlePain reports

Pain experience and mood disorders during the lockdown of the COVID-19 pandemic in the United States: an opportunistic study.

Luana Colloca, Sharon Thomas, Margaret Yin, Nathaniel R Haycock, Yang Wang

Abstract read
In one paragraph

Article in Pain reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. The Nocebo Effect.Annual review of pharmacology and toxicology · 2024
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Psychosocial Factors Predict COVID-19 Vaccine Side Effects.Psychotherapy and psychosomatics · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Luana CollocaPain and Translational Symptom Science, University of Maryland School of Nursing, Baltimore, MD, USA.ORCID 0000-0002-6503-4709
Sharon ThomasPain and Translational Symptom Science, University of Maryland School of Nursing, Baltimore, MD, USA.
Margaret YinPain and Translational Symptom Science, University of Maryland School of Nursing, Baltimore, MD, USA.
Nathaniel R HaycockPain and Translational Symptom Science, University of Maryland School of Nursing, Baltimore, MD, USA.ORCID 0000-0002-0538-458X
Yang WangPain and Translational Symptom Science, University of Maryland School of Nursing, Baltimore, MD, USA.

Funding

Neural correlates of hypoalgesia driven by observationR01AT010333 · NCCIH · UNIVERSITY OF MARYLAND BALTIMORE · PI COLLOCA, LUANA · 2019 to 2023
$3.7M
Neural Mechanisms of Immersive Virtual Reality in Chronic PainR01AT011347 · NCCIH · UNIVERSITY OF MARYLAND BALTIMORE · PI Luana Colloca · 2021 to 2026
$3.2M
Chronic orofacial pain: genetics, cognitive-emotional factors, and endogenous modulatory systemsR01DE025946 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI COLLOCA, LUANA · 2016 to 2019
$2.1M
NCCIH NIH HHS R01 AT010333NCCIH NIH HHS R01 AT011347NIDCR NIH HHS R01 DE025946
6 · The paper itself

Abstract

introductionThe unknown and uncontrollable situation of the coronavirus disease 2019 (COVID-19) pandemic may have triggered changes in pain, anxiety, and depression along with a perception of nonspecific COVID-19 symptoms.

objectivesWe determined how anxiety, depression, and pain outcomes varied during the "Stay-at-Home" order compared with the prepandemic period and whether nonspecific COVID-19 symptoms would occur.

methodsWe conducted an online survey to opportunistically reassess clinical anxiety, depression, pain intensity, and pain interference while controlling for somatic symptom severity during the prepandemic and Stay-at-Home order period. During the Stay-at-Home period, anxiety, depression, pain intensity, and pain interference were reassessed. Coping strategies were assessed as a critical factor influencing pain behaviors. In addition, we explored the occurrence of nonspecific COVID-19 symptoms with an ad hoc survey referencing the Centers for Disease Control and Prevention publicly available COVID-19 symptoms.

resultsWe observed a significant increase in depression and anxiety levels during the Stay-at-Home period. Coping strategy changes (eg, increased exercise) were linked to lower pain severity and interference which improved overall. Participants who self-reported nonspecific COVID-19 symptoms had higher prepandemic depression. Among the 72 participants not diagnosed with COVID-19, 70.8% of the participants experienced symptoms resembling those associated with COVID-19.

conclusionWe suggest the parallel between pain outcome improvement and worsening anxiety and depression during the Stay-at-Home order might reflect a shift in symptoms, indicating that those patients with underlying mood disorders may require more help than they did before the pandemic.

Indexed as

ExpectationsIllness behaviorsMood disorderNoceboTemporomandibular disorder

Identifiers

PMID34589641
PMCPMC8476053

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.